NEURL2 and MYH6

Number of citations of the paper that reports this interaction (PubMedID 35551201)
41

Data Source:
BioGRID (enzymatic study)

		NEURL2	MYH6
Description		neuralized E3 ubiquitin protein ligase 2	myosin heavy chain 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Stress Fiber Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Z Disc Myosin Filament
	Molecular Function	Ubiquitin Protein Ligase Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Myosin Phosphatase Activity Protein Kinase Binding Actin Filament Binding
	Biological Process	Protein Ubiquitination Intracellular Signal Transduction	In Utero Embryonic Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Muscle System Process Muscle Contraction Striated Muscle Contraction Adult Heart Development Visceral Muscle Development Regulation Of Heart Contraction Regulation Of Blood Pressure Cardiac Muscle Hypertrophy In Response To Stress Actin Filament-based Movement Muscle Filament Sliding Myofibril Assembly Sarcomere Organization ATP Metabolic Process Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Regulation Of Heart Growth
Pathways		Neddylation	Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS			Aortic coarctation ( 29590334) Atrial fibrillation ( 30061737) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Heart rate ( 23583979) P wave duration ( 28794112) P wave terminal force ( 28794112) PR interval ( 30046033 32439900) Pulse pressure ( 28135244 27618448 27618447 30578418) Resting heart rate ( 28270201 27798624 29769521 23183192 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure ( 27618447)
Interacting Genes		7 interacting genes: CTNNB1 ELOC MYH6 PDCD6IP RBX1 SMN1 UBE2H	7 interacting genes: CALCOCO1 CALCOCO2 ESR1 HSPB2 NEURL2 POLR2A TRIM63
Entrez ID		140825	4624
HPRD ID		16353	01171
Ensembl ID		ENSG00000124257	ENSG00000197616
Uniprot IDs		Q9BR09	P13533
PDB IDs
Enriched GO Terms of Interacting Partners?		Proteolysis Involved In Protein Catabolic Process Z Disc Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Cul5-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Transcription Corepressor Binding Post-translational Protein Modification Nucleobase-containing Compound Biosynthetic Process Cytosol Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Macromolecule Catabolic Process Visceral Muscle Development Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Oviduct Development Nucleobase-containing Compound Metabolic Process Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Cell-cell Junction Assembly Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Cellular Component Assembly Bicellular Tight Junction Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis RNA Metabolic Process	Beta-catenin Binding Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis Zinc Ion Binding TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Cytoplasm Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Hormone-mediated Signaling Pathway Somatic Muscle Development RNA-directed RNA Polymerase Activity Microfibril Binding RNA-templated Transcription Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity 5'-3' RNA Polymerase Activity Xenophagy Positive Regulation Of Autophagosome Maturation Skeletal Muscle Adaptation Striated Muscle Atrophy Nitric-oxide Synthase Regulator Activity Intracellular Receptor Signaling Pathway Muscle Atrophy Prostate Gland Growth Vagina Development Estrogen Response Element Binding
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