MYH6

Description		myosin heavy chain 6
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Z Disc Myosin Filament
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Calmodulin Binding ATP Binding Myosin Phosphatase Activity Protein Kinase Binding Actin Filament Binding
	Biological Process	In Utero Embryonic Development Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Muscle System Process Muscle Contraction Striated Muscle Contraction Adult Heart Development Visceral Muscle Development Regulation Of Heart Contraction Regulation Of Blood Pressure Cardiac Muscle Hypertrophy In Response To Stress Actin Filament-based Movement Muscle Filament Sliding Myofibril Assembly Sarcomere Organization ATP Metabolic Process Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction Regulation Of Heart Growth
Pathways		Striated Muscle Contraction
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Atrial septal defect
GWAS		Aortic coarctation ( 29590334) Atrial fibrillation ( 30061737) Diastolic blood pressure ( 30578418) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063) Electrocardiographic traits (multivariate) ( 32602732) Heart rate ( 23583979) P wave duration ( 28794112) P wave terminal force ( 28794112) PR interval ( 30046033 32439900) Pulse pressure ( 28135244 27618448 27618447 30578418) Resting heart rate ( 28270201 27798624 29769521 23183192 20639392) RR interval (heart rate) ( 30679814) Systolic blood pressure ( 27618447)
Interacting Genes		7 interacting genes: CALCOCO1 CALCOCO2 ESR1 HSPB2 NEURL2 POLR2A TRIM63
Entrez ID		4624
HPRD ID		01171
Ensembl ID		ENSG00000197616
Uniprot IDs		P13533
PDB IDs
Enriched GO Terms of Interacting Partners?		Beta-catenin Binding Nuclear Estrogen Receptor Activity Regulation Of Branching Involved In Prostate Gland Morphogenesis Zinc Ion Binding TFIIB-class Transcription Factor Binding Prostate Epithelial Cord Elongation Cytoplasm Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Mammary Gland Branching Involved In Pregnancy Antral Ovarian Follicle Growth Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Hormone-mediated Signaling Pathway Somatic Muscle Development RNA-directed RNA Polymerase Activity Microfibril Binding RNA-templated Transcription Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Skeletal Muscle Atrophy Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Regulation Of Nitric-oxide Synthase Activity 5'-3' RNA Polymerase Activity Xenophagy Positive Regulation Of Autophagosome Maturation Skeletal Muscle Adaptation Striated Muscle Atrophy Nitric-oxide Synthase Regulator Activity Intracellular Receptor Signaling Pathway Muscle Atrophy Prostate Gland Growth Vagina Development Estrogen Response Element Binding
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