ADHFE1 and LIPC

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ADHFE1	LIPC
Gene Name		alcohol dehydrogenase, iron containing, 1	lipase, hepatic
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Extracellular Space High-density Lipoprotein Particle
	Molecular Function	Metal Ion Binding Hydroxyacid-oxoacid Transhydrogenase Activity	Phospholipase Activity Triglyceride Lipase Activity Heparin Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding
	Biological Process	2-oxoglutarate Metabolic Process Molecular Hydrogen Transport Cellular Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process	Fatty Acid Biosynthetic Process Cholesterol Metabolic Process Triglyceride Catabolic Process Very-low-density Lipoprotein Particle Remodeling Intermediate-density Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phosphatidylcholine Catabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Triglyceride Homeostasis
Pathways		Pyruvate metabolism and Citric Acid (TCA) cycle Interconversion of 2-oxoglutarate and 2-hydroxyglutarate The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS			Age-related macular degeneration ( 20385819 20385826 23455636 21665990) Alzheimer's disease (cognitive decline) ( 23535033) Amyotrophic lateral sclerosis ( 18084291) Cardiovascular disease risk factors ( 21943158) Cholesterol, total ( 19060911 20686565) Cognitive performance ( 20125193) HDL cholesterol ( 18193043 18193044 20864672 19060906 23505323 19060910 19060911 20686565) Hematological and biochemical traits ( 20139978) Lipid metabolism phenotypes ( 22286219 19936222) Metabolic syndrome ( 22399527) Metabolic syndrome (bivariate traits) ( 21386085) Metabolite levels ( 23281178 22916037 19043545) Non-small cell lung cancer ( 23144319) Obesity-related traits ( 23251661) Phospholipid levels (plasma) ( 22359512) Red blood cell traits ( 23222517) Triglycerides ( 18193043 20686565)
Protein-Protein Interactions		2 interactors: GNAQ LIPC	3 interactors: ADHFE1 APOB LRP1
Entrez ID		137872	3990
HPRD ID		12428	01058
Ensembl ID		ENSG00000147576	ENSG00000166035
Uniprot IDs		Q8IWW8	A6H8L5 E7EUJ1 P11150
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate-density Lipoprotein Particle Remodeling Phosphatidylcholine Catabolic Process Very-low-density Lipoprotein Particle Remodeling Chylomicron Remnant Clearance Phospholipase C-activating Dopamine Receptor Signaling Pathway Neuron Remodeling Glycerophospholipid Catabolic Process Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling Regulation Of Melanocyte Differentiation Maternal Behavior High-density Lipoprotein Particle Remodeling Reverse Cholesterol Transport Triglyceride Catabolic Process Regulation Of Catenin Import Into Nucleus Regulation Of Developmental Pigmentation Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling Phospholipid Catabolic Process Neuron Maturation Plasma Lipoprotein Particle Clearance Triglyceride Homeostasis Dopamine Receptor Signaling Pathway Acylglycerol Homeostasis Forebrain Neuron Development Activation Of Phospholipase C Activity Alcohol Catabolic Process Phosphatidylcholine Metabolic Process Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase C Activity Regulation Of Plasma Lipoprotein Particle Levels Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Forebrain Neuron Differentiation Glutamate Receptor Signaling Pathway Developmental Pigmentation Sterol Transport Cholesterol Transport Embryonic Digit Morphogenesis Positive Regulation Of Phospholipase Activity Cholesterol Homeostasis Forebrain Generation Of Neurons Sterol Homeostasis Regulation Of Phospholipase Activity Action Potential Positive Regulation Of Lipase Activity Protein Stabilization Triglyceride Metabolic Process Neutral Lipid Metabolic Process Central Nervous System Neuron Development Cholesterol Metabolic Process	Lipoprotein Transport Artery Morphogenesis Artery Development Phototransduction, Visible Light Retinoid Metabolic Process Diterpenoid Metabolic Process Detection Of Visible Light Phototransduction Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Sterol Metabolic Process Beta-amyloid Clearance Lipoprotein Metabolic Process Detection Of Abiotic Stimulus Molecular Hydrogen Transport Steroid Metabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Response To Light Stimulus Alcohol Metabolic Process Receptor-mediated Endocytosis Response To Selenium Ion Blood Vessel Morphogenesis Small Molecule Metabolic Process Very-low-density Lipoprotein Particle Assembly Response To Radiation Triglyceride Mobilization Blood Vessel Development Low-density Lipoprotein Particle Remodeling Regulation Of Phospholipase A2 Activity Vasculature Development Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Detection Of Stimulus 2-oxoglutarate Metabolic Process Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Smooth Muscle Cell Migration Lipoprotein Catabolic Process Protein-lipid Complex Assembly Endocytosis Positive Regulation Of Cholesterol Storage Positive Regulation Of Cholesterol Efflux Cellular Response To Prostaglandin Stimulus Positive Regulation Of Cholesterol Transport Regulation Of Cholesterol Biosynthetic Process Triglyceride Catabolic Process Regulation Of Cholesterol Efflux Low-density Lipoprotein Particle Clearance Aorta Morphogenesis Acylglycerol Catabolic Process Plasma Lipoprotein Particle Remodeling
Tagcloud ?			abcg2 accessed americans architecture blacks contrasting direction eagle ethnicities ethnicity exposing fourteen genotypic hispanic mexican nhanes phenome phewas pleiotropic pleiotropy protoporphyrin race replicated replicating rs1800588 rs2231142 snp surveys whites
Tagcloud (Difference) ?			abcg2 accessed americans architecture blacks contrasting direction eagle ethnicities ethnicity exposing fourteen genotypic hispanic mexican nhanes phenome phewas pleiotropic pleiotropy protoporphyrin race replicated replicating rs1800588 rs2231142 snp surveys whites
Tagcloud (Intersection) ?