LYPD2 and POU4F2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LYPD2	POU4F2
Description		LY6/PLAUR domain containing 2	POU class 4 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Side Of Membrane	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Promoter-specific Chromatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Axonogenesis Axon Guidance Heart Development Sensory Perception Of Sound Cell Differentiation Neuron Differentiation Estrogen Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Cellular Response To Insulin Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of D-glucose Import Axon Extension Neuromuscular Process Controlling Balance Regulation Of DNA-binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS			Malaria ( 31844061) Metabolite levels ( 23823483)
Interacting Genes		1 interacting genes: POU4F2	77 interacting genes: ADAMTSL4 ALPP CCN3 CD46 CERCAM CHIC2 CHRD CHRDL2 COL8A1 CYP21A2 CYSRT1 DLX3 ESR1 FAM86C1P GRN HDHD3 HIGD2B IGFBP6 IGFL1 INCA1 KPRP KRT31 KRT35 KRT38 KRT83 KRTAP1-1 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE1F LCE2C LCE5A LCN2 LGALS13 LHX2 LYPD2 MMADHC NFKBID NOTO PCSK5 PLSCR2 RBP3 RBPMS RGS19 SPRY4 TGFB1 TRIM42 VWC2
Entrez ID		137797	5458
HPRD ID		14334	00220
Ensembl ID		ENSG00000197353	ENSG00000151615
Uniprot IDs		F1T0L0 Q6UXB3	Q12837
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Retinal Ganglion Cell Axon Guidance Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding Regulation Of Axon Guidance Regulation Of Adipose Tissue Development Positive Regulation Of DNA Binding Ganglion Development Regulation Of Transcription Regulatory Region DNA Binding Retinal Ganglion Cell Axon Guidance Estrogen Receptor Signaling Pathway Positive Regulation Of Osteoclast Differentiation Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Retina Development In Camera-type Eye P53 Binding Promoter-specific Chromatin Binding Neuromuscular Process Controlling Balance Negative Regulation Of DNA-binding Transcription Factor Activity Euchromatin Cellular Response To Estradiol Stimulus Regulation Of Axon Extension Axon Extension Positive Regulation Of D-glucose Import Positive Regulation Of Axon Extension Regulation Of Osteoclast Differentiation Steroid Hormone Receptor Signaling Pathway Positive Regulation Of D-glucose Transmembrane Transport Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Positive Regulation Of Axonogenesis Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of D-glucose Transmembrane Transport Regulation Of DNA Binding Positive Regulation Of Binding Regulation Of D-glucose Import Negative Regulation Of Neuron Differentiation Neuron Projection Extension Cellular Response To Insulin Stimulus Nuclear Receptor-mediated Signaling Pathway Signal Transduction By P53 Class Mediator Positive Regulation Of Myeloid Cell Differentiation Response To Estradiol Neuromuscular Process Developmental Cell Growth Regulation Of Myeloid Leukocyte Differentiation Developmental Growth Involved In Morphogenesis Regulation Of Axonogenesis Sensory Perception Of Sound Hormone-mediated Signaling Pathway Sensory Perception Of Mechanical Stimulus	Intermediate Filament Keratin Filament Hair Cycle Epidermis Development Keratinization Protein Binding Cytosol Structural Constituent Of Skin Epidermis Identical Protein Binding
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