COX8A and MAGEA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COX8A	MAGEA4
Description		cytochrome c oxidase subunit 8A	MAGE family member A4
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV	Nucleus
	Molecular Function	Cytochrome-c Oxidase Activity Protein Binding	Protein Binding Histone Deacetylase Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Proton Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Cycle
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs		Cholic Acid N-Formylmethionine
Diseases
GWAS		Bipolar disorder ( 31043756)
Interacting Genes		5 interacting genes: AMBP BATF EDDM3B MAGEA4 NPM1	27 interacting genes: AMOT AMOTL2 APP ARNT2 BEX2 COX8A GTF3C1 HDDC3 HLA-A LDLRAP1 PICK1 POT1 PSMD10 PUDP RAD18 TEKT4 TIGD5 TK1 TRIM69 TSPYL1 TSPYL4 TXN2 UBXN6 UQCRB UVSSA WBP2 ZNF576
Entrez ID		1351	4103
HPRD ID		00468	02167
Ensembl ID		ENSG00000176340	ENSG00000147381
Uniprot IDs		P10176 Q53XN1	P43358
PDB IDs		5Z62 8D4T	1I4F 2WA0 6TRN 6TRO 7UOA 8ES8 8ES9 8FJA 9BD3
Enriched GO Terms of Interacting Partners?		Myeloid Leukocyte Differentiation Myeloid Cell Differentiation T Cell Differentiation Involved In Immune Response Mononuclear Cell Differentiation Cytochrome C Metabolic Process T Cell Activation Involved In Immune Response Leukocyte Differentiation IgE Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Collagen Fibril Binding Calcium Oxalate Binding Cytochrome Metabolic Process Protein Homodimerization Activity IgA Binding Leukocyte Activation Involved In Immune Response Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Cell Activation Involved In Immune Response Serotonin Secretion By Platelet T Cell Differentiation Lymphocyte Activation Involved In Immune Response Fc-gamma Receptor III Complex Myeloid Leukocyte Activation Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity Regulation Of Endoribonuclease Activity T-helper 17 Cell Differentiation Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Positive Regulation Of Centrosome Duplication Matrix Side Of Mitochondrial Inner Membrane Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Apoptotic Process Regulation Of Adaptive Immune Response Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Granular Component Negative Regulation Of Programmed Cell Death	Establishment Of Cell Polarity Involved In Ameboidal Cell Migration
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