ADAT2 and NAV2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		ADAT2	NAV2
Description		adenosine deaminase tRNA specific 2	neuron navigator 2
Image
GO Annotations	Cellular Component	Nucleoplasm	Interstitial Matrix Nucleus Nucleoplasm Extracellular Matrix
	Molecular Function	Catalytic Activity Protein Binding TRNA-specific Adenosine Deaminase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding TRNA-specific Adenosine-34 Deaminase Activity	Nucleotide Binding Helicase Activity Protein Binding ATP Binding Heparin Binding Hydrolase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity
	Biological Process	TRNA Wobble Adenosine To Inosine Editing TRNA Processing	Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Nervous System Development Sensory Perception Of Sound Sensory Perception Of Smell Locomotory Behavior Optic Nerve Development Glossopharyngeal Nerve Development Vagus Nerve Development Cerebellar Cortex Development Neurogenesis
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Chronotype ( 30696823)	Adverse response to drug ( 30420678) Atrial fibrillation ( 29892015 30061737) Bone mineral density x blood lead interaction in current smokers (2df test) ( 29518117) Brain morphology (MOSTest) ( 32665545) Coronary artery aneurysm in Kawasaki disease ( 27171184) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) General cognitive ability ( 29844566) Hepatitis ( 25705159) L1-L4 bone mineral density x serum urate levels interaction ( 34046847) Lateral thalamic nuclei volume ( 34006833) Low susceptibility to hepatitis C infection ( 31206233) Macular thickness ( 30535121) Monobrow ( 27182965) Obesity-related traits ( 23251661) PR interval ( 32439900 30046033) Response to inhaled glucocorticoid treatment in asthma (change in FEV1) ( 25601762) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Smoking initiation (ever regular vs never regular) ( 30679032) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Waist circumference ( 28552196)
Interacting Genes		4 interacting genes: APP NAV2 SGTB SMARCD1	12 interacting genes: ADAT2 APC CFAP58 ING4 ING5 MORF4L1 PIAS2 PRPF3 PSTPIP1 RBM15 RBM15B RRAS
Entrez ID		134637	89797
HPRD ID		13132	07385
Ensembl ID		ENSG00000189007	ENSG00000166833
Uniprot IDs		Q7Z6V5	A7E2D6 Q8IVL1
PDB IDs		3DH1	2YRN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression, Epigenetic Protein-folding Chaperone Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glossopharyngeal Nerve Development Regulation Of Systemic Arterial Blood Pressure By Baroreceptor Feedback Vagus Nerve Development Acetylcholine Receptor Activator Activity PTB Domain Binding Protein Homooligomerization Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Locomotory Behavior Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Heparin Binding Molecular Adaptor Activity TRC Complex Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway System Development Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission Protein Complex Oligomerization NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Epigenetic Regulation Of Gene Expression Axon Choice Point Recognition Interstitial Matrix Cerebellar Cortex Development Heparan Sulfate Binding Signaling Receptor Activator Activity Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure	DNA Replication-dependent Chromatin Disassembly Nuclear Speck RNA N6-methyladenosine Methyltransferase Complex Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Histone H3K4me3 Reader Activity Histone Acetyltransferase Complex Chromatin Organization RNA Modification Nucleoplasm Protein Acetylation Fibroblast Proliferation TRNA Wobble Adenosine To Inosine Editing TRNA-specific Adenosine-34 Deaminase Activity Macromolecule Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process RNA Methylation Regulation Of DNA Biosynthetic Process RNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?