SHROOM1 and MCAM

Number of citations: 0 (PubMedID 19137261)
Data Source: BioGRID (fluorescent resonance energy transfer)

		SHROOM1	MCAM
Name		shroom family member 1	melanoma cell adhesion molecule
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Microtubule Adherens Junction Apical Plasma Membrane Cortical Actin Cytoskeleton Apical Junction Complex	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane
	Molecular Function	Actin Binding Myosin II Binding Actin Filament Binding	Laminin Receptor Activity Protein Binding
	Biological Process	Cell Morphogenesis Actin Filament Bundle Assembly	Angiogenesis Glomerular Filtration Cell Adhesion Anatomical Structure Morphogenesis Positive Regulation Of Cell Migration Vascular Wound Healing
Pathways		None	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
GWAS		Apolipoprotein A-IV levels ( 27412012 ) Asthma ( 31619474 )	Plateletcrit ( 32888494 )
Interacting Genes		2 interacting genes: CLK1 MCAM	6 interacting genes: ADRB2 ATF7IP FYN LGALS3 PTK2B SHROOM1
Entrez ID		134549	4162
HPRD ID		10655	01120
Ensembl ID		ENSG00000164403	ENSG00000076706
Uniprot IDs		A6NN40 Q2M3G4	P43121
PDB IDs		Not available	6LYN
GO Terms Enriched among Interactors		Renal Filtration Laminin Receptor Activity Glomerular Filtration Angiogenesis Involved In Wound Healing Vascular Wound Healing Protein Serine/threonine/tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity	Glutamate Receptor Signaling Pathway Regulation Of Metal Ion Transport Regulation Of Monoatomic Ion Transport Postsynaptic Density, Intracellular Component Bone Resorption Positive Regulation Of Excitatory Postsynaptic Potential Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Calcium Ion Transport Vascular Endothelial Growth Factor Receptor Signaling Pathway Ligand-gated Ion Channel Signaling Pathway Cellular Response To Amyloid-beta Modulation Of Excitatory Postsynaptic Potential Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Calcium Ion Import Response To Amyloid-beta Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Neurotransmitter Receptor Regulator Activity Cellular Response To Glycine Response To Singlet Oxygen Regulation Of Bone Mineralization Cell Body Positive Regulation Of Cellular Component Organization Multicellular Organismal-level Homeostasis Beta2-adrenergic Receptor Activity Negative Regulation Of Multicellular Organismal Process Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of B Cell Chemotaxis Lymphocyte Activation Response To Glycine Positive Regulation Of Protein Localization To Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Regulation Of Nervous System Process Regulation Of Ossification Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Leukocyte Activation Protein Tyrosine Kinase Activity Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Regulation Of Multicellular Organismal Development Regulation Of Cell Shape Transmembrane Transporter Binding Norepinephrine Binding Positive Regulation Of Neuron Projection Development