SLC31A1 and PRKAB1

Number of citations of the paper that reports this interaction (PubMedID 36807336)
53

Data Source:
BioGRID (enzymatic study)

		SLC31A1	PRKAB1
Description		solute carrier family 31 member 1	protein kinase AMP-activated non-catalytic subunit beta 1
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GO Annotations	Cellular Component	Endosome Late Endosome Plasma Membrane Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Early Endosome Membrane Late Endosome Membrane Recycling Endosome Recycling Endosome Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nucleotide-activated Protein Kinase Complex Protein-containing Complex
	Molecular Function	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Protein Binding Silver Ion Transmembrane Transporter Activity Identical Protein Binding Xenobiotic Transmembrane Transporter Activity	Protein Binding Protein Kinase Binding
	Biological Process	Angiogenesis Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Copper Ion Import Plasma Membrane Copper Ion Transport Copper Ion Transmembrane Transport Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Xenobiotic Transport Protein Complex Oligomerization Establishment Of Localization In Cell Silver Ion Transmembrane Transport	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Signal Transduction Cellular Response To Nutrient Levels Nail Development Positive Regulation Of Cold-induced Thermogenesis
Pathways		Metal ion SLC transporters	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenosine phosphate Adenosine phosphate Metformin Acetylsalicylic acid Fostamatinib
Diseases
GWAS		Hematology traits ( 23303382) Monocyte percentage of white cells ( 32888494)	Basophil count ( 32888494) Inflammatory bowel disease ( 26192919) Lymphocyte percentage of white cells ( 32888494) Mitochondrial heteroplasmy measurement ( 33731350) Monocyte count ( 32888494) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Ulcerative colitis ( 26192919) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: PRKAA1 PRKAB1 PRKAG2 UBC	13 interacting genes: ACACA AGL APP F10 GRB2 MAP3K7 MAPK6 NDUFA7 PRKAA1 PRKAA2 PRKAG1 PRKAG2 SLC31A1
Entrez ID		1317	5564
HPRD ID		04362	04116
Ensembl ID		ENSG00000136868	ENSG00000111725
Uniprot IDs		O15431	Q9Y478
PDB IDs		2LS2 2LS3 2LS4	4CFE 4CFF 4ZHX 5EZV 5ISO 6B1U 6C9F 6C9G 6C9H 6C9J 7MYJ 8BIK
Enriched GO Terms of Interacting Partners?		Nucleotide-activated Protein Kinase Complex AMP-activated Protein Kinase Activity Fatty Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Cellular Response To Nutrient Levels Fatty Acid Metabolic Process Sterol Biosynthetic Process Regulation Of Glycolytic Process Cellular Response To Glucose Starvation Small Molecule Biosynthetic Process Monocarboxylic Acid Metabolic Process Response To Nutrient Levels Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Lipid Biosynthetic Process Regulation Of Purine Nucleotide Metabolic Process Steroid Biosynthetic Process Negative Regulation Of Glucosylceramide Biosynthetic Process Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Sterol Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Positive Regulation Of Small Molecule Metabolic Process Cold Acclimation Positive Regulation Of Mitochondrial Transcription Cellular Response To Starvation Phosphorylase Kinase Regulator Activity Regulation Of Carbon Utilization Lipid Metabolic Process Protein Localization To Lipid Droplet Response To Starvation Steroid Metabolic Process Negative Regulation Of Ceramide Biosynthetic Process Negative Regulation Of Tubulin Deacetylation Negative Regulation Of Sphingolipid Biosynthetic Process CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process CAMKK-AMPK Signaling Cascade Nail Development Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly CAMP-dependent Protein Kinase Regulator Activity Regulation Of Lipid Metabolic Process Regulation Of Small Molecule Metabolic Process Small Molecule Metabolic Process Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell Phosphatidylethanolamine Biosynthetic Process Regulation Of Mitochondrial Transcription	AMP-activated Protein Kinase Activity Nucleotide-activated Protein Kinase Complex Regulation Of Glycolytic Process Regulation Of Carbohydrate Catabolic Process Regulation Of ATP Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Fatty Acid Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Cellular Response To Glucose Starvation Positive Regulation Of Small Molecule Metabolic Process Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Glycolytic Process Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Cellular Response To Prostaglandin Stimulus Carboxylic Acid Biosynthetic Process Response To Prostaglandin E Phosphate-containing Compound Metabolic Process Regulation Of Carbon Utilization Fatty Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of ATP Metabolic Process Regulation Of Small Molecule Metabolic Process Protein Localization To Lipid Droplet Sterol Biosynthetic Process Negative Regulation Of Tubulin Deacetylation CAMP-dependent Protein Kinase Activity Negative Regulation Of Hepatocyte Apoptotic Process Cellular Response To Starvation Regulation Of Tubulin Deacetylation Lipid Droplet Disassembly CAMP-dependent Protein Kinase Regulator Activity Small Molecule Biosynthetic Process Protein Kinase Binding Monocarboxylic Acid Metabolic Process Response To Starvation Response To Nutrient Levels Phosphatidylethanolamine Biosynthetic Process ATP Binding Organophosphate Biosynthetic Process Lipid Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Cellular Response To Nutrient Levels Steroid Biosynthetic Process AMP Binding Positive Regulation Of TOR Signaling Response To Hormone Intracellular Copper Ion Homeostasis Protein Kinase Regulator Activity
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