OTOL1 and IFT80

		OTOL1	IFT80
Description		otolin 1	intraflagellar transport 80
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer	Cytoplasm Centrosome Cytoskeleton Cilium Intraciliary Transport Particle B Ciliary Basal Body Cell Projection Ciliary Tip 9+0 Non-motile Cilium
	Molecular Function	Calcium Ion Binding Metal Ion Binding
	Biological Process	Otolith Mineralization Protein Homooligomerization	Skeletal System Development Ossification Osteoblast Differentiation Endochondral Ossification Chondrocyte Differentiation Growth Plate Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Apoptotic Process Establishment Or Maintenance Of Cell Polarity Smoothened Signaling Pathway Canonical NF-kappaB Signal Transduction Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Tissue Development Gene Expression Proteasomal Protein Catabolic Process Negative Regulation Of Keratinocyte Proliferation Protein Ubiquitination Spinal Cord Development Osteoclast Differentiation Osteoblast Proliferation Multicellular Organism Growth Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Intraciliary Anterograde Transport Odontogenesis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Keratinocyte Proliferation Tooth Eruption Cilium Organization Stem Cell Differentiation Protein Stabilization Cartilage Development Limb Development Cilium Assembly Bone Development Bone Morphogenesis Articular Cartilage Development Odontoblast Differentiation Stem Cell Proliferation Receptor Localization To Non-motile Cilium Response To Inositol Non-motile Cilium Assembly Cartilage Homeostasis Negative Regulation Of Non-canonical Wnt Signaling Pathway
Pathways			Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Aging (time to death) ( 21782286) Alcohol consumption (drinks per week) ( 30643258) Hepcidin/ferritin ratio ( 27846281) Schizophrenia ( 28991256 30285260) Schizophrenia x sex interaction ( 34099189) Type 2 diabetes ( 30130595)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Bipolar disorder ( 31043756) LDL cholesterol ( 30275531) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Malaria ( 31844061)
Interacting Genes			2 interacting genes: PLXNA2 UBXN10
Entrez ID		131149	57560
HPRD ID		19083	13853
Ensembl ID		ENSG00000182447	ENSG00000068885
Uniprot IDs		A6NHN0	Q9P2H3
PDB IDs
Enriched GO Terms of Interacting Partners?		Intraciliary Transport Particle B Tooth Eruption Articular Cartilage Development Growth Plate Cartilage Chondrocyte Differentiation Negative Regulation Of Non-canonical Wnt Signaling Pathway Bone Mineralization Involved In Bone Maturation Response To Inositol Cartilage Homeostasis Receptor Localization To Non-motile Cilium Odontoblast Differentiation Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Protein Localization To Non-motile Cilium Protein Localization To Ciliary Membrane Growth Plate Cartilage Development 9+0 Non-motile Cilium Osteoblast Proliferation Protein Ubiquitination Protein Modification By Small Protein Conjugation Intraciliary Anterograde Transport Post-translational Protein Modification Cartilage Development Involved In Endochondral Bone Morphogenesis Negative Regulation Of Keratinocyte Proliferation Host-mediated Suppression Of Symbiont Invasion Regulation Of Non-canonical Wnt Signaling Pathway Spinal Cord Development Endochondral Ossification Keratinocyte Proliferation Neuroepithelial Cell Differentiation Bone Morphogenesis Ciliary Tip Regulation Of Keratinocyte Proliferation Osteoclast Differentiation Intraciliary Transport Non-motile Cilium Assembly Negative Regulation Of Signal Transduction Chondrocyte Differentiation Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Protein Localization To Cilium Limb Development Non-canonical Wnt Signaling Pathway Canonical NF-kappaB Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Connective Tissue Development Bone Development Protein Modification Process Stem Cell Proliferation Smoothened Signaling Pathway Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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