NMS and NMUR1

Number of citations of the paper that reports this interaction (PubMedID 15635449)
52

Data Source:
HPRD (in vitro)

		NMS	NMUR1
Description		neuromedin S	neuromedin U receptor 1
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GO Annotations	Cellular Component	Extracellular Region	Plasma Membrane Cilium Membrane
	Molecular Function		Neuromedin U Receptor Activity G Protein-coupled Receptor Activity Neuropeptide Receptor Activity Neuromedin U Binding
	Biological Process	Neuropeptide Signaling Pathway	Chloride Transport Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Calcium-mediated Signaling
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Educational attainment ( 25201988) Household income ( 27818178) Household income (MTAG) ( 31844048) Regular attendance at a religious group ( 29970889)	Corneal astigmatism ( 30306274) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		1 interacting genes: NMUR1	2 interacting genes: NMS NMU
Entrez ID		129521	10316
HPRD ID		17638	16039
Ensembl ID		ENSG00000204640	ENSG00000171596
Uniprot IDs		A0A250SI41 Q5H8A3	Q9HB89
PDB IDs		7W56 7W57	7W53 7W56
Enriched GO Terms of Interacting Partners?		Neuromedin U Receptor Activity Neuromedin U Binding Neuropeptide Receptor Activity Smooth Muscle Contraction Positive Regulation Of Calcium-mediated Signaling Neuropeptide Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Inorganic Anion Transport Regulation Of Calcium-mediated Signaling Monoatomic Anion Transport Chloride Transport Calcium-mediated Signaling Muscle Contraction Muscle System Process	Neuropeptide Signaling Pathway Neuromedin U Receptor Binding Type 2 Neuromedin U Receptor Binding Negative Regulation Of Gastric Emptying Positive Regulation Of Stomach Fundus Smooth Muscle Contraction Feeding Behavior Type 1 Neuromedin U Receptor Binding Positive Regulation Of Prolactin Secretion Regulation Of Grooming Behavior Negative Regulation Of Eating Behavior Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Sensory Perception Of Pain Regulation Of Gastric Motility Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Regulation Of Eating Behavior Gastric Acid Secretion Regulation Of Gastric Acid Secretion Negative Regulation Of Feeding Behavior Proximal Dendrite Positive Regulation Of Heat Generation Positive Regulation Of Systemic Arterial Blood Pressure Multicellular Organismal-level Homeostasis Mitotic G1 DNA Damage Checkpoint Signaling Musculoskeletal Movement Mitotic G1/S Transition Checkpoint Signaling Proline-rich Region Binding Regulation Of Sensory Perception Of Pain Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Type I Interferon-mediated Signaling Pathway Spinal Cord Motor Neuron Differentiation Regulation Of Circadian Sleep/wake Cycle Acid Secretion Regulation Of Feeding Behavior Positive Regulation Of Heart Rate Photoperiodism Positive Regulation Of Smooth Muscle Contraction Eating Behavior Positive Regulation Of Blood Pressure G Protein-coupled Receptor Signaling Pathway Temperature Homeostasis Terminal Bouton Positive Regulation Of Heart Contraction Cell Differentiation In Spinal Cord Homeostasis Of Number Of Cells Within A Tissue Insulin-like Growth Factor Receptor Signaling Pathway Rescue Of Stalled Ribosome Regulation Of Type I Interferon-mediated Signaling Pathway Ribosome Disassembly Negative Regulation Of Translational Initiation Neuromuscular Process Controlling Balance
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