NAXE and APOA2

Number of citations of the paper that reports this interaction (PubMedID 11991719)
0

Data Source:
HPRD (in vitro)

		NAXE	APOA2
Description		NAD(P)HX epimerase	apolipoprotein A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Cilium Cell Body Extracellular Exosome	Extracellular Region Extracellular Space Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Exosome Blood Microparticle
	Molecular Function	Nucleotide Binding Protein Binding Isomerase Activity Identical Protein Binding Metal Ion Binding NAD(P)HX Epimerase Activity	Signaling Receptor Binding Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Enzyme Binding Heat Shock Protein Binding Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Receptor Ligand Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding Cholesterol Transfer Activity
	Biological Process	Sprouting Angiogenesis Lipid Transport Regulation Of Cholesterol Efflux Negative Regulation Of Angiogenesis Membrane Raft Distribution Nicotinamide Nucleotide Metabolic Process Metabolite Repair	Negative Regulation Of Cytokine Production Involved In Immune Response Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Lipid Transport Signal Transduction Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Cholesterol Transport Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Positive Regulation Of Interleukin-8 Production Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Diacylglycerol Catabolic Process Positive Regulation Of Phagocytosis Protein Stabilization Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Negative Regulation Of Cholesterol Import Cellular Response To Lipoprotein Particle Stimulus Cellular Response To Amyloid-beta
Pathways		Nicotinate metabolism	PPARA activates gene expression Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Retinoid metabolism and transport Retinoid metabolism and transport
Drugs			Zinc Copper Zinc acetate
Diseases			Familial amyloidosis
GWAS
Interacting Genes		3 interacting genes: APOA1 APOA2 MAPK6	31 interacting genes: ABCA13 APOC1 APOD APOF AQP6 C4A CATSPER1 CIAO2A CREB3 CYBC1 GET1 GJA8 HSD17B13 KIR2DL3 LMNA MUC1 NAXE NDRG1 PANX1 PDZK1IP1 PLTP PSCA SCARB1 SLC7A1 SSMEM1 STOM TAB1 TMEM45A TMEM82 TREM2 VKORC1
Entrez ID		128240	336
HPRD ID		16397	00129
Ensembl ID		ENSG00000163382	ENSG00000158874
Uniprot IDs		Q8NCW5	P02652
PDB IDs
Enriched GO Terms of Interacting Partners?		Peptidyl-methionine Modification High-density Lipoprotein Particle Receptor Binding Apolipoprotein Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Protein Oxidation Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Intestinal Cholesterol Absorption High-density Lipoprotein Particle Clearance Spherical High-density Lipoprotein Particle High-density Lipoprotein Particle Assembly Regulation Of Intestinal Lipid Absorption High-density Lipoprotein Particle Binding Chylomicron Phospholipid Efflux Regulation Of Intestinal Absorption Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Lipid Transporter Activity Cholesterol Transfer Activity Plasma Lipoprotein Particle Assembly Phosphatidylcholine Biosynthetic Process Protein-lipid Complex Assembly Plasma Lipoprotein Particle Clearance Cholesterol Efflux Lipoprotein Metabolic Process Negative Regulation Of Cytokine Production Involved In Immune Response Plasma Lipoprotein Particle Remodeling Cellular Response To Lipoprotein Particle Stimulus Protein-containing Complex Remodeling Cholesterol Binding Cellular Response To Amyloid-beta Phosphatidylcholine Metabolic Process Heat Shock Protein Binding Regulation Of Cholesterol Transport Response To Amyloid-beta Cholesterol Transport Positive Regulation Of Phagocytosis Sterol Transport Phospholipid Transport Cholesterol Homeostasis Sterol Homeostasis Regulation Of Phagocytosis Cholesterol Metabolic Process Phospholipid Binding Blood Microparticle Sterol Metabolic Process Regulation Of Cytokine Production Involved In Immune Response Receptor Ligand Activity	Regulation Of Cholesterol Transport Lipid Transport High-density Lipoprotein Particle Binding Low-density Lipoprotein Particle Binding Regulation Of Lipid Transport High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Regulation Of Phosphatidylcholine Catabolic Process Lipid Transporter Activity Sterol Transport Respiratory Burst After Phagocytosis Cholesterol Efflux Plasma Lipoprotein Particle Remodeling Detection Of Lipopolysaccharide Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Positive Regulation Of Cholesterol Transport Protein-containing Complex Remodeling Regulation Of Phospholipid Catabolic Process Regulation Of Cholesterol Efflux Monoatomic Anion Channel Activity Positive Regulation Of Apoptotic Cell Clearance Respiratory Burst Involved In Defense Response Organophosphate Ester Transport Regulation Of Phosphatidylcholine Metabolic Process Regulation Of Apoptotic Cell Clearance Organic Hydroxy Compound Transport Cholesterol Transport Endoplasmic Reticulum Regulation Of Endocytosis Detection Of Molecule Of Bacterial Origin Phagocytosis, Recognition Kinase Activator Activity Regulation Of Lipid Metabolic Process Phosphatidylethanolamine Binding Regulation Of Transport Carbohydrate Derivative Transport Apolipoprotein Binding Ceramide Transport Positive Regulation Of Lipid Transport Membrane Phospholipid Transport Gap Junction Channel Activity Respiratory Burst Regulation Of Phagocytosis Gap Junction Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Efflux Cholesterol Metabolic Process Sterol Metabolic Process
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