PUSL1 and UBE2J2

		PUSL1	UBE2J2
Description		pseudouridine synthase like 1	ubiquitin conjugating enzyme E2 J2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion	Ubiquitin Ligase Complex Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	RNA Binding Pseudouridine Synthase Activity Isomerase Activity TRNA Pseudouridine Synthase Activity	Nucleotide Binding Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Pseudouridine Synthesis TRNA Processing RNA Modification TRNA Pseudouridine Synthesis	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Response To Unfolded Protein Protein Ubiquitination ERAD Pathway Protein K6-linked Ubiquitination Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Inflammatory bowel disease ( 28067908) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 28067908)
Interacting Genes		2 interacting genes: APP FBXO7	22 interacting genes: AQP6 ATP13A2 ELOVL7 FBXO7 HECW1 HERC4 ITCH MARCHF6 MDM2 MGRN1 NEDD4L PRKN RBP1 RNF10 TMEM14B TRIM25 TRIM59 UBA1 UBC UBE2G2 WWP2 XIAP
Entrez ID		126789	118424
HPRD ID		08301	15600
Ensembl ID		ENSG00000169972	ENSG00000160087
Uniprot IDs		Q8N0Z8	A6NGS0 Q8N2K1
PDB IDs			2F4W
Enriched GO Terms of Interacting Partners?		Ubiquitin Ligase Complex Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Notch Signaling Pathway Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Lewy Body Core Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Post-translational Protein Modification Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Regulation Of Neuron Apoptotic Process Cellular Response To Manganese Ion Ubiquitin-protein Transferase Activity	Protein Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Macromolecule Catabolic Process Protein Modification Process Proteolysis Catabolic Process Protein K48-linked Ubiquitination Protein Monoubiquitination Proteasomal Protein Catabolic Process Transferase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Protein Metabolic Process Protein Autoubiquitination Macromolecule Metabolic Process Positive Regulation Of Protein Linear Polyubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Signal Transduction ERAD Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling Ubiquitin Ligase Complex Ligase Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Autophagy Of Mitochondrion Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Manganese Ion Potassium Channel Inhibitor Activity Response To Oxidative Stress Protein K29-linked Ubiquitination Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Response To Manganese Ion Positive Regulation Of Protein Catabolic Process Cellular Response To Oxidative Stress Negative Regulation Of Protein Localization Regulation Of Protein Transport Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Polyubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Exosomal Secretion
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