PLRG1 and MIRLET7A2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		PLRG1	MIRLET7A2
Description		pleiotropic regulator 1	microRNA let-7a-2
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Fibrillar Center Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Nuclear Speck Nuclear Membrane U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	RISC Complex
	Molecular Function	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Protein Localization To Nucleus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	MiRNA-mediated Post-transcriptional Gene Silencing
Pathways		mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Fibrinogen ( 21757653) Fibrinogen levels ( 28107422 29403010)
Interacting Genes		14 interacting genes: APP CDC5L CEBPA CNN1 HNRNPM MIR106B MIR205 MIR93 MIRLET7A2 MIRLET7E MIRLET7G MIRLET7I MX1 ZSCAN1	95 interacting genes: AIMP1 AIMP2 APOBEC3B AQR ATXN2L C1QBP CDC40 CDC5L CHERP DARS1 DDX1 DDX21 DDX23 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 P3H1 PDCD11 PGAM5 PLOD1 PLRG1 PRMT1 PTBP1 PTCD3 PUM1 PUM2 QARS1 RARS1 RBM14 RBM17 RBM4 RTCB SAFB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR
Entrez ID		5356	406882
HPRD ID		16181
Ensembl ID		ENSG00000171566	ENSG00000198975
Uniprot IDs		O43660
PDB IDs		4YVD 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7AAV 7ABF 7ABG 7ABI 7DH6 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Macromolecule Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Extracellular Vesicle Positive Regulation Of Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Metabolic Process Extracellular Space RNA Destabilization MRNA Destabilization Regulation Of Gene Expression Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Interleukin-8 Production Negative Regulation Of Cell Population Proliferation Positive Regulation Of MRNA Metabolic Process Regulation Of Osteoblast Differentiation Negative Regulation Of SMAD Protein Signal Transduction Regulation Of Translation Regulation Of Inflammatory Response Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Vascular Endothelial Growth Factor Production Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Amyloid-beta Protein Domain Specific Binding RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Metabolic Process Response To Amyloid-beta Negative Regulation Of Osteoblast Differentiation	RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Metabolic Process MRNA Processing Nucleobase-containing Compound Metabolic Process MRNA Binding MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Macromolecule Metabolic Process Catalytic Step 2 Spliceosome Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Metabolic Process Aminoacyl-tRNA Synthetase Multienzyme Complex Nucleoplasm Nucleus MiRNA Binding Cytoplasmic Stress Granule Regulation Of RNA Splicing Regulation Of Translation Ribonucleoprotein Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of RNA Stability Regulation Of MRNA Stability Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Processing MiRNA Processing Negative Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Metabolic Process TRNA Aminoacylation MRNA Stabilization U2 SnRNP Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Translation Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression CRD-mediated MRNA Stabilization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?