MFSD12 and SSMEM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		MFSD12	SSMEM1
Description		major facilitator superfamily domain containing 12	serine rich single-pass membrane protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Membrane Melanosome Membrane Melanosome	Membrane
	Molecular Function	Protein Binding Symporter Activity Cysteine Transmembrane Transporter Activity	Protein Binding
	Biological Process	Amino Acid Transport Carbohydrate Transport Melanin Biosynthetic Process Pigment Metabolic Process Involved In Pigmentation Regulation Of Melanin Biosynthetic Process Negative Regulation Of Melanin Biosynthetic Process Cysteine Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Cutaneous malignant melanoma ( 32341527) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Nevus count or cutaneous melanoma ( 32341527) Skin pigmentation ( 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583)	Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		4 interacting genes: ADRB2 CD79A SSMEM1 TMEM14B	99 interacting genes: ALG3 APOA2 AQP1 AQP10 AQP3 ARLN ATP6V0C BET1 BLCAP C11orf24 C1QL4 C5 CCL4L2 CDIPT CDS2 CLRN2 CMTM7 CSGALNACT2 CTSA CXCL16 CXCL9 CYB561 CYBC1 DEFB103A DEFB103B DEFB121 EFNA5 EMD ERG28 ERMP1 FAM3C FATE1 FDPS FPR2 GJB2 GPHB5 GPR151 HMOX2 JAGN1 LAT LEPROTL1 LHFPL5 LNPEP MARCHF2 MCRS1 MFSD12 MFSD6 MIP MMD2 MS4A13 NINJ2 NIPAL4 NRM PGAP2 PLPP1 PLPP4 PLPP6 PLPPR2 RHD RTP2 RUSF1 S1PR5 SERP1 SLC35A1 SLC35E3 SLC35H1 SLC38A1 SLC38A7 SLC39A2 SLC39A9 SLC41A1 SLC41A2 SLC61A1 STX8 TAP1 TAS2R10 TLCD1 TM6SF2 TMEM128 TMEM14A TMEM14C TMEM203 TMEM218 TMEM222 TMEM239 TMEM243 TMEM45A TMEM60 TMEM86A TMEM86B TMEM97 TMPPE TNF TRARG1 UNC93B1 UPK1B VAMP4 YIPF6 ZFPL1
Entrez ID		126321	136263
HPRD ID		12704	14060
Ensembl ID		ENSG00000161091	ENSG00000165120
Uniprot IDs		Q6NUT3	A0A3B3ISA2 Q8WWF3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity IgM B Cell Receptor Complex B Cell Receptor Complex Positive Regulation Of Autophagosome Maturation Heat Generation Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Identical Protein Binding Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Heme Biosynthetic Process	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Water Channel Activity Phosphatidate Phosphatase Activity Transmembrane Transport Glycerol Transmembrane Transport Carbohydrate Transport Water Transport Polyol Transmembrane Transport Phospholipid Metabolic Process Alkenylglycerophosphocholine Hydrolase Activity Fluid Transport Phospholipid Dephosphorylation Plasma Membrane Channel Activity Geranyl Diphosphate Metabolic Process Positive Regulation Of Neutrophil Activation Diacylglycerol Diphosphate Phosphatase Activity Magnesium Ion Transmembrane Transport Magnesium Ion Transmembrane Transporter Activity Magnesium Ion Transport Carbohydrate Transmembrane Transport Amide Transport Glycerol Channel Activity Lipid Phosphatase Activity Renal Water Absorption One-carbon Compound Transport Urea Transmembrane Transporter Activity Farnesyl Diphosphate Metabolic Process Gap Junction-mediated Intercellular Transport Sphingosine-1-phosphate Phosphatase Activity CCR6 Chemokine Receptor Binding Antigen Processing And Presentation Of Peptide Antigen Response To Bacterium Chemotaxis Lysophosphatidic Acid Phosphatase Activity Inorganic Cation Transmembrane Transporter Activity Renal Water Transport Neutrophil Differentiation Glutamine Transport L-glutamine Transmembrane Transporter Activity Locomotion Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Ammonium Channel Activity Urea Transmembrane Transport Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
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