MFSD12

Description		major facilitator superfamily domain containing 12
Image		No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Late Endosome Plasma Membrane Membrane Melanosome Membrane Melanosome
	Molecular Function	Protein Binding Symporter Activity Cysteine Transmembrane Transporter Activity
	Biological Process	Amino Acid Transport Carbohydrate Transport Melanin Biosynthetic Process Pigment Metabolic Process Involved In Pigmentation Regulation Of Melanin Biosynthetic Process Negative Regulation Of Melanin Biosynthetic Process Cysteine Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Cutaneous malignant melanoma ( 32341527) Facial pigmentation measurement (polar light) ( 32835660) Facial pigmentation measurement (UV light) ( 32835660) Nevus count or cutaneous melanoma ( 32341527) Skin pigmentation ( 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583)
Interacting Genes		4 interacting genes: ADRB2 CD79A SSMEM1 TMEM14B
Entrez ID		126321
HPRD ID		12704
Ensembl ID		ENSG00000161091
Uniprot IDs		Q6NUT3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Positive Regulation Of Mini Excitatory Postsynaptic Potential Response To Psychosocial Stress Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Beta2-adrenergic Receptor Activity IgM B Cell Receptor Complex B Cell Receptor Complex Positive Regulation Of Autophagosome Maturation Heat Generation Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Identical Protein Binding Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Heme Biosynthetic Process
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