CNGA1 and SLC24A1

Number of citations of the paper that reports this interaction (PubMedID 12693957)
0

Data Source:
HPRD (in vivo)

		CNGA1	SLC24A1
Description		cyclic nucleotide gated channel subunit alpha 1	solute carrier family 24 member 1
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Plasma Membrane Membrane Intracellular Cyclic Nucleotide Activated Cation Channel Complex Photoreceptor Outer Segment Membrane Rod Photoreceptor Outer Segment	Plasma Membrane Membrane Outer Membrane Neuronal Cell Body
	Molecular Function	Nucleotide Binding Monoatomic Ion Channel Activity Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Intracellularly CAMP-activated Cation Channel Activity Intracellularly CGMP-activated Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Protein Binding CAMP Binding CGMP Binding	Calcium Channel Activity Protein Binding Calcium, Potassium:sodium Antiporter Activity Symporter Activity Antiporter Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Visual Perception Sensory Perception Of Chemical Stimulus Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Monoatomic Cation Transmembrane Transport	Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Visual Perception Response To Light Intensity Sodium Ion Transmembrane Transport Transmembrane Transport Long-term Synaptic Potentiation Long-term Synaptic Depression Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane
Pathways		Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade	Activation of the phototransduction cascade Sodium/Calcium exchangers Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)
Drugs		Dequalinium
Diseases		Retinitis pigmentosa (RP)
GWAS		Spondylosis ( 33332786)	Hemoglobin levels ( 32327693) Iron status biomarkers (ferritin levels) ( 33536631) Logical memory (delayed recall) in normal cognition ( 29274321) Mean corpuscular hemoglobin ( 20139978)
Interacting Genes		1 interacting genes: SLC24A1	1 interacting genes: CNGA1
Entrez ID		1259	9187
HPRD ID		00445	04685
Ensembl ID		ENSG00000198515	ENSG00000074621
Uniprot IDs		P29973	B4DUG1 B4E1W0 F5H127 F5H483 O60721
PDB IDs		7LFT 7LFW 7LFX 7LFY 7LG1 7RH9 7RHG 7RHH 7RHI 7RHJ 7RHK 7RHL
Enriched GO Terms of Interacting Partners?		Outer Membrane Visual Perception Sensory Perception Of Light Stimulus Calcium, Potassium:sodium Antiporter Activity Pigment Granule Aggregation In Cell Center Primary Palate Development Sensory Perception BBSome Calcium Ion Import Across Plasma Membrane Response To Light Intensity Calcium Ion Import Into Cytosol Long-term Synaptic Depression Nervous System Process Pigment Granule Localization Establishment Of Melanosome Localization Digestive Tract Morphogenesis Melanosome Localization Melanosome Transport Pigment Granule Transport Calcium Ion Import Negative Regulation Of Synaptic Transmission Long-term Synaptic Potentiation Non-motile Cilium Assembly Ciliary Membrane Limb Development System Process Heart Looping Embryonic Heart Tube Morphogenesis Photoreceptor Outer Segment Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Antiporter Activity Symporter Activity Inorganic Cation Import Across Plasma Membrane Smoothened Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Determination Of Bilateral Symmetry Roof Of Mouth Development Determination Of Left/right Symmetry	Intracellular Cyclic Nucleotide Activated Cation Channel Complex Intracellularly CAMP-activated Cation Channel Activity CGMP Binding Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Photoreceptor Outer Segment Membrane Intracellularly CGMP-activated Cation Channel Activity Rod Photoreceptor Outer Segment HMG Box Domain Binding Response To Gonadotropin-releasing Hormone CAMP Response Element Binding Pristanate-CoA Ligase Activity Phytanate-CoA Ligase Activity Fatty Acid Transmembrane Transporter Activity Very Long-chain Fatty Acid-CoA Ligase Activity Very Long-chain Fatty Acid Catabolic Process Methyl-branched Fatty Acid Metabolic Process Long-chain Fatty Acid-CoA Ligase Activity Cholate-CoA Ligase Activity Arachidonate-CoA Ligase Activity Fatty Acid Alpha-oxidation Lipid Import Into Cell Long-chain Fatty Acid Import Into Cell Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase COPI-coated Vesicle Long-chain Fatty Acid Transmembrane Transporter Activity CAMP Binding Bile Acid Biosynthetic Process Fatty-acyl-CoA Biosynthetic Process Protein Localization To Golgi Apparatus BHLH Transcription Factor Binding
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