ZG16B and UBAC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ZG16B	UBAC1
Description		zymogen granule protein 16B	UBA domain containing 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Membrane Apicolateral Plasma Membrane Extracellular Exosome	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Carbohydrate Binding	Protein Binding Polyubiquitin Modification-dependent Protein Binding Proteasome Binding
	Biological Process	Cell Migration	Protein Ubiquitination Protein Maturation
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		10 interacting genes: GOLGA2 HAUS8 NEIL3 PNMA1 SGTA SGTB UBAC1 UBQLN1 UBQLN2 UBQLN4	37 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A FAS HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MECOM MGAT3 NEDD4L PLAAT2 PLEKHB2 POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBC UBQLN2 WWP2 ZDHHC17 ZG16B
Entrez ID		124220	10422
HPRD ID		14024	12170
Ensembl ID		ENSG00000162078	ENSG00000130560
Uniprot IDs		A0A0C4DGN4 G8H6I3 Q96DA0	A0A140VK64 Q9BSL1
PDB IDs		3AQG	2DAI
Enriched GO Terms of Interacting Partners?		Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of ERAD Pathway TRC Complex Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Proteasomal Protein Catabolic Process Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Endoplasmic Reticulum Membrane ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Autophagy Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Identical Protein Binding Regulation Of Cellular Response To Stress Establishment Of Protein Localization To Endoplasmic Reticulum Regulation Of Macroautophagy Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Centrosome Cycle Proteolysis Involved In Protein Catabolic Process Organelle Assembly Autophagy Negative Regulation Of Store-operated Calcium Channel Activity MCM Complex Binding Nuclear Microtubule Protein Targeting To Membrane Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Microtubule Organizing Center Organization Negative Regulation Of Catabolic Process Cellular Response To Stress Negative Regulation Of G Protein-coupled Receptor Internalization Nuclear Proteasome Complex Spindle Assembly Autophagosome Assembly Autophagosome Organization Negative Regulation Of Autophagy Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Negative Regulation Of Autophagosome Maturation Macromolecule Catabolic Process Positive Regulation Of Protein Glycosylation BAT3 Complex Binding Proteasomal Protein Catabolic Process Negative Regulation Of Clathrin-dependent Endocytosis Depurination	Ubiquitin Protein Ligase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Collateral Sprouting In Absence Of Injury Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Catabolic Process Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Regulation Of Protein Metabolic Process Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Macromolecule Catabolic Process Protein Catabolic Process Positive Regulation Of Aggrephagy Transferase Activity Post-translational Protein Modification Negative Regulation Of Potassium Ion Export Across Plasma Membrane Positive Regulation Of Protein Catabolic Process Apoptotic Process Positive Regulation Of Metabolic Process Programmed Cell Death Cell Death Negative Regulation Of Signal Transduction Regulation Of Proteolysis Proteolysis Protein Targeting To Vacuole Potassium Channel Inhibitor Activity Ubiquitin-protein Transferase Activity Regulation Of Programmed Cell Death Identical Protein Binding Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Signal Transduction Establishment Of Protein Localization To Vacuole Protein Targeting To Vacuole Involved In Autophagy Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Segment Specification Proteasomal Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Collateral Sprouting Regulation Of Developmental Growth Catabolic Process Receptor Catabolic Process
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