AGAP1 and UGT1A3

		AGAP1	UGT1A3
Description		ArfGAP with GTPase domain, ankyrin repeat and PH domain 1	UDP glucuronosyltransferase family 1 member A3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Postsynaptic Endosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding GTPase Activity GTPase Activator Activity Protein Binding GTP Binding Phospholipid Binding Zinc Ion Binding Metal Ion Binding	Retinoic Acid Binding Enzyme Inhibitor Activity UDP-glycosyltransferase Activity Glucuronosyltransferase Activity Transferase Activity Glycosyltransferase Activity Enzyme Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Protein Transport Regulation Of Modification Of Postsynaptic Structure	Lipid Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Estrogen Metabolic Process Flavonoid Metabolic Process Bile Acid Secretion Retinoic Acid Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Vitamin D3 Metabolic Process
Pathways			Glucuronidation NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis Aspirin ADME Atorvastatin ADME Prednisone ADME
Drugs
Diseases
GWAS		Adult body size ( 32376654) Anterior thalamic nuclei volume ( 34006833) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Craniofacial microsomia ( 26853712) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Menarche (age at onset) ( 23667675) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)	Bilirubin levels ( 32084209) Hair greying ( 26926045) Liver disease biomarker ( 30576415) Low density lipoprotein cholesterol levels ( 32154731) Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 23093944 33031748) Total bilirubin levels ( 29403010) Total bilirubin levels in HIV-1 infection ( 25884002)
Interacting Genes		16 interacting genes: APP ARF1 ARF6 CDC42 DYRK1A GRB7 GUCY1A1 GUCY1B1 RAC1 RHOA RSPH14 SMN1 SRC TK1 WEE2-AS1 ZNF534
Entrez ID		116987	54659
HPRD ID		16359	07566
Ensembl ID		ENSG00000157985	ENSG00000288702
Uniprot IDs		B2RZG9 E7EUN2 Q9UPQ3	P35503 Q5DT01
PDB IDs		7EB6
Enriched GO Terms of Interacting Partners?		Regulation Of Supramolecular Fiber Organization GTP Binding Membrane Invagination Thioesterase Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Regulation Of Endocytosis G Protein Activity Regulation Of Cell-substrate Junction Organization Guanylate Cyclase Complex, Soluble Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Establishment Of Epithelial Cell Polarity Positive Regulation Of Locomotion Postsynapse Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Lamellipodium Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Cell Junction Assembly Neuron Projection Organization Regulation Of Receptor-mediated Endocytosis Cell Junction Organization Regulation Of Actin Filament Organization Positive Regulation Of Cytokinesis Negative Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Nucleotide Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Synapse Organization Non-canonical Wnt Signaling Pathway Regulation Of Lamellipodium Organization Signaling Receptor Activator Activity Positive Regulation Of Stress Fiber Assembly Guanylate Cyclase Activity Regulation Of Cytoskeleton Organization GTPase Activity Establishment Or Maintenance Of Cell Polarity Circulatory System Process Nitric Oxide-cGMP-mediated Signaling Regulation Of Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Glutamatergic Synapse Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Podosome Assembly Flavonoid Metabolic Process Actin Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Focal Adhesion Assembly	Postsynaptic Endosome Regulation Of Modification Of Synaptic Structure Regulation Of Modification Of Postsynaptic Structure Phospholipid Binding
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