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CCDC85A and NEK2
Number of citations of the paper that reports this interaction (PMID
21900206
)
27
Data Source:
BioGRID
(two hybrid)
CCDC85A
NEK2
Gene Name
coiled-coil domain containing 85A
NIMA-related kinase 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Kinetochore
Condensed Chromosome Kinetochore
Condensed Nuclear Chromosome
Spindle Pole
Nucleus
Nucleolus
Cytoplasm
Centrosome
Cytosol
Microtubule
Midbody
Protein Complex
Intercellular Bridge
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Binding
Metal Ion Binding
Biological Process
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Blastocyst Development
Protein Phosphorylation
Organelle Organization
Chromosome Segregation
Mitotic Nuclear Division
Regulation Of Mitotic Nuclear Division
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of DNA Binding
Regulation Of Mitotic Centrosome Separation
Protein Autophosphorylation
Spindle Assembly
Centrosome Separation
Cell Division
Meiotic Cell Cycle
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Mitotic Spindle Assembly
Negative Regulation Of Centriole-centriole Cohesion
Pathways
Organelle biogenesis and maintenance
APC/C:Cdc20 mediated degradation of mitotic proteins
Assembly of the primary cilium
G2/M Transition
Anchoring of the basal body to the plasma membrane
Regulation of PLK1 Activity at G2/M Transition
APC/C-mediated degradation of cell cycle proteins
Cell Cycle, Mitotic
Loss of proteins required for interphase microtubule organization from the centrosome
Loss of Nlp from mitotic centrosomes
Regulation of mitotic cell cycle
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Centrosome maturation
Mitotic G2-G2/M phases
Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Menarche (age at onset) (
21102462
)
Protein-Protein Interactions
3 interactors:
NEK2
PFDN1
STMN2
23 interactors:
CCDC85A
CEP250
CHGA
CSN2
CTNNB1
DCTN1
EDRF1
EIF4A2
GIT1
IFT140
IMMT
MAD1L1
MAPK1
MCC
NDC80
NEK11
PDE4DIP
PPP1CA
PPP1CC
PPP1R2
SPTBN4
TCF25
TPM3
Entrez ID
114800
4751
HPRD ID
19098
04953
Ensembl ID
ENSG00000055813
ENSG00000117650
Uniprot IDs
Q96PX6
P51955
PDB IDs
2JAV
2W5A
2W5B
2W5H
2WQO
2XK3
2XK4
2XK6
2XK7
2XK8
2XKC
2XKD
2XKE
2XKF
2XNM
2XNN
2XNO
2XNP
4A4X
4AFE
Enriched GO Terms of Interacting Partners
?
Regulation Of Microtubule Cytoskeleton Organization
Negative Regulation Of Centriole-centriole Cohesion
Negative Regulation Of Cytoskeleton Organization
Regulation Of Microtubule-based Process
Regulation Of Centriole-centriole Cohesion
Regulation Of Mitotic Centrosome Separation
Positive Regulation Of Microtubule Depolymerization
Regulation Of Cytoskeleton Organization
Negative Regulation Of Microtubule Polymerization
Centrosome Separation
Positive Regulation Of Protein Depolymerization
Mitotic Spindle Assembly
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Cellular Response To Nerve Growth Factor Stimulus
Regulation Of Microtubule Polymerization
Positive Regulation Of Protein Complex Disassembly
Regulation Of Organelle Organization
Negative Regulation Of Microtubule Depolymerization
Mitotic Spindle Organization
Negative Regulation Of DNA Binding
Regulation Of Centrosome Cycle
Negative Regulation Of Microtubule Polymerization Or Depolymerization
Cytoskeleton Organization
Centrosome Cycle
'de Novo' Posttranslational Protein Folding
'de Novo' Protein Folding
Multicellular Organismal Development
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Anatomical Structure Development
Regulation Of Microtubule Polymerization Or Depolymerization
Cell Cycle
Mitotic Sister Chromatid Segregation
Regulation Of Chromosome Segregation
Spindle Assembly
Regulation Of DNA Binding
Sister Chromatid Segregation
Negative Regulation Of Protein Polymerization
Negative Regulation Of Protein Complex Disassembly
Centrosome Organization
Negative Regulation Of Binding
Developmental Process
Blastocyst Development
Regulation Of Protein Depolymerization
Microtubule Organizing Center Organization
Cerebellum Development
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Neuron Projection Development
Regulation Of Mitotic Nuclear Division
Regulation Of Protein Complex Disassembly
Metencephalon Development
Cell Cycle
Regulation Of Centriole-centriole Cohesion
Glycogen Metabolic Process
Mitotic Cell Cycle
Polysaccharide Metabolic Process
Regulation Of Organelle Organization
Triglyceride Catabolic Process
Entrainment Of Circadian Clock By Photoperiod
Movement Of Cell Or Subcellular Component
Cell Cycle Process
Photoperiodism
Entrainment Of Circadian Clock
Acylglycerol Catabolic Process
Energy Reserve Metabolic Process
Mitotic Cell Cycle Process
Microtubule-based Process
Cell Division
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of RNA-directed RNA Polymerase Activity
Regulation Of Metaphase Plate Congression
Regulation Of Cytoskeleton Organization
Cellular Protein Localization
Cellular Carbohydrate Metabolic Process
Centrosome Cycle
Cellular Response To Growth Factor Stimulus
MAPK Import Into Nucleus
Negative Regulation Of Mitotic Cell Cycle, Embryonic
Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development
Schwann Cell Proliferation
Cellular Response To Insulin-like Growth Factor Stimulus
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition
Response To Growth Factor
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Chromosome Segregation
Regulation Of Signal Transduction
Cell Morphogenesis
Circadian Regulation Of Gene Expression
Energy Derivation By Oxidation Of Organic Compounds
Response To Abiotic Stimulus
Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process
Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation
Renal Inner Medulla Development
Renal Outer Medulla Development
Mesenchymal Cell Proliferation Involved In Lung Development
Glial Cell Fate Determination
Oviduct Development
Mitotic Nuclear Division
Neuron Differentiation
Establishment Of Organelle Localization
Tagcloud
?
called
complementary
cyclins
dissociated
dnas
ectopic
elucidate
eventually
g2
gst
hec
heptad
hydrolyzes
inhibits
interacts
leucine
mitosis
mitotic
modulate
mss1
p45
proteasome
proteolysis
pull
repeats
seventh
smc1
smc2
telophase
Tagcloud (Difference)
?
called
complementary
cyclins
dissociated
dnas
ectopic
elucidate
eventually
g2
gst
hec
heptad
hydrolyzes
inhibits
interacts
leucine
mitosis
mitotic
modulate
mss1
p45
proteasome
proteolysis
pull
repeats
seventh
smc1
smc2
telophase
Tagcloud (Intersection)
?