PTH2 and PTH2R

Number of citations of the paper that reports this interaction (PMID 10854439)
11

Data Source:
HPRD (in vitro, in vivo)

		PTH2	PTH2R
Gene Name		parathyroid hormone 2	parathyroid hormone 2 receptor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function		Parathyroid Hormone Receptor Activity
	Biological Process	Neuropeptide Signaling Pathway	G-protein Coupled Receptor Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: PTH2R	5 interactors: CALM1 GRHPR HMG20A PTH PTH2
Entrez ID		113091	5746
HPRD ID		16328	03276
Ensembl ID		ENSG00000142538	ENSG00000144407
Uniprot IDs		Q96A98	P49190
PDB IDs
Enriched GO Terms of Interacting Partners?			Positive Regulation Of CAMP Biosynthetic Process Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Response To Fibroblast Growth Factor Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Positive Regulation Of Anoikis Regulation Of High Voltage-gated Calcium Channel Activity G-protein Coupled Receptor Signaling Pathway Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Hormone-mediated Apoptotic Signaling Pathway Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Glyoxylate Metabolic Process Negative Regulation Of Gene Expression Response To Metal Ion Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Phosphoprotein Phosphatase Activity Positive Regulation Of Glycogen Biosynthetic Process Response To Parathyroid Hormone Negative Regulation Of Anoikis Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Glycogen Catabolic Process Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Response To Inorganic Substance Negative Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Anoikis Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Protein Dephosphorylation Negative Regulation Of Cation Channel Activity Polysaccharide Catabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Nitric Oxide Metabolic Process Negative Regulation Of Cellular Metabolic Process Response To Growth Factor Regulation Of Protein Autophosphorylation Reactive Nitrogen Species Metabolic Process Rhodopsin Mediated Signaling Pathway Response To Vitamin D
Tagcloud ?		5b beginning bgp biomechanical bmd ctx femoral gla isoenzyme lumbar microarchitecture microstructural orchidectomized orchidectomy orx osteocalcin osteoporosis parathyroid pth1 resorption restore simulated tartrate telopeptide totally trabecular wistar worsening	alters articular cdk2 cdks cfk2 cfk2r chondrocyte chondrocytes chondrocytic clones generating hypertrophic lesser localizing master metalloproteinase newborn parathyroid plate prehypertrophic presently resting restricting skeleton sox9 substantiating tip39 tuberoinfundibular
Tagcloud (Difference) ?		5b beginning bgp biomechanical bmd ctx femoral gla isoenzyme lumbar microarchitecture microstructural orchidectomized orchidectomy orx osteocalcin osteoporosis pth1 resorption restore simulated tartrate telopeptide totally trabecular wistar worsening	alters articular cdk2 cdks cfk2 cfk2r chondrocyte chondrocytes chondrocytic clones generating hypertrophic lesser localizing master metalloproteinase newborn plate prehypertrophic presently resting restricting skeleton sox9 substantiating tip39 tuberoinfundibular
Tagcloud (Intersection) ?		parathyroid