SLCO2B1 and ICAM1

		SLCO2B1	ICAM1
Description		solute carrier organic anion transporter family member 2B1	intercellular adhesion molecule 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane	Immunological Synapse Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Membrane Raft Extracellular Exosome
	Molecular Function	Organic Anion Transmembrane Transporter Activity Bile Acid Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Xenobiotic Metabolic Process Monoatomic Ion Transport Organic Anion Transport Bile Acid And Bile Salt Transport Prostaglandin Transport Heme Catabolic Process Sodium-independent Organic Anion Transport Transmembrane Transport Transport Across Blood-brain Barrier	Regulation Of Leukocyte Mediated Cytotoxicity Immune Effector Process T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Immune Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Membrane To Membrane Docking Cell Adhesion Mediated By Integrin Adhesion Of Symbiont To Host Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Leukocyte Migration Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Glucose Stimulus T Cell Extravasation Cell-cell Adhesion Regulation Of Ruffle Assembly Cellular Response To Oxygen-containing Compound Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Organic anion transport by SLCO transporters	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs		Gemfibrozil Telaprevir	Natalizumab Hyaluronic acid Nafamostat
Diseases			Allograft rejection
GWAS			Blood protein levels ( 30072576) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte count ( 27863252 32888494) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 18604267 21533024 31217265) White blood cell count ( 32888494)
Interacting Genes		1 interacting genes: APP	16 interacting genes: CYSRT1 EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KRTAP10-8 MSN SLC3A2 SPN UBQLN2
Entrez ID		11309	3383
HPRD ID		07061	00996
Ensembl ID		ENSG00000137491	ENSG00000090339
Uniprot IDs		A0A0A0MTF1 O94956	A0A384MEK5 P05362
PDB IDs			1D3E 1D3I 1D3L 1IAM 1IC1 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U 7BG7
Enriched GO Terms of Interacting Partners?		Acetylcholine Receptor Activator Activity Membrane Raft Amyloid-beta Complex PTB Domain Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Integrin Binding Regulation Of Leukocyte Migration Regulation Of Response To Calcium Ion Cell Activation Involved In Immune Response Amylin Binding Response To Amyloid-beta Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Amyloid-beta Lipoprotein Particle Positive Regulation Of Leukocyte Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of ERK1 And ERK2 Cascade Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of ERK1 And ERK2 Cascade Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Membrane To Membrane Docking T Cell Antigen Processing And Presentation T Cell Extravasation Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition External Side Of Plasma Membrane Receptor-mediated Virion Attachment To Host Cell Heparan Sulfate Binding Signaling Receptor Activator Activity T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell	Cell Surface Leukocyte Cell-cell Adhesion Regulation Of Vesicle-mediated Transport Cell Adhesion Molecule Binding Cell Activation External Side Of Plasma Membrane Cell-cell Adhesion Uropod Leukocyte Activation Integrin AlphaL-beta2 Complex Integrin AlphaM-beta2 Complex Microvillus Cell-substrate Adhesion Cell Adhesion T Cell Activation Interleukin-2 Binding Interleukin-2 Receptor Activity ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Integrin Complex Positive Regulation Of Cell Adhesion Gland Morphogenesis Negative Regulation Of Dopamine Metabolic Process Positive Regulation Of Metabolic Process Cell-matrix Adhesion Plasma Membrane Raft Negative Regulation Of Catecholamine Metabolic Process Membrane To Membrane Docking Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Transport Regulation Of Developmental Process Basolateral Plasma Membrane Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of Neutrophil Degranulation Regulation Of Multicellular Organismal Process Lymphocyte Activation Regulation Of ERK1 And ERK2 Cascade Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Regulation Of Immune System Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Macromolecule Metabolic Process Complement Component C3b Binding Heat Shock Protein Binding Basal Plasma Membrane Interleukin-2-mediated Signaling Pathway Positive Regulation Of Protein Localization To Endosome Positive Regulation Of Cell-cell Adhesion Regulation Of Cell Adhesion
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