CHI3L1 and TSPAN15

		CHI3L1	TSPAN15
Description		chitinase 3 like 1	tetraspanin 15
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Extracellular Matrix Specific Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome	Endosome Endoplasmic Reticulum Lumen Cytosol Plasma Membrane Cell Surface Membrane Nuclear Body Cell Junction Late Endosome Membrane Tetraspanin-enriched Microdomain
	Molecular Function	Chitinase Activity Extracellular Matrix Structural Constituent Protein Binding Chitin Binding Carbohydrate Binding	Protein Binding Enzyme Binding
	Biological Process	Carbohydrate Metabolic Process Chitin Catabolic Process Apoptotic Process Inflammatory Response Activation Of NF-kappaB-inducing Kinase Activity Response To Mechanical Stimulus Positive Regulation Of Peptidyl-threonine Phosphorylation Lung Development Positive Regulation Of Interleukin-8 Production Response To Tumor Necrosis Factor Positive Regulation Of Angiogenesis Cartilage Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-1 Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor	Regulation Of Notch Signaling Pathway Negative Regulation Of Notch Signaling Pathway Regulation Of Membrane Protein Ectodomain Proteolysis Protein Maturation Protein Localization To Plasma Membrane
Pathways		Neutrophil degranulation	Amyloid fiber formation
Drugs
Diseases
GWAS		Asthma ( 31959851) Blood protein levels in cardiovascular risk ( 28369058) Clozapine-induced agranulocytosis ( 25187353) Metabolite levels ( 23823483) YKL-40 levels ( 18403759)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Response to taxane treatment (paclitaxel) ( 23006423) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Thrombosis ( 26908601) Type 2 diabetes ( 32499647) Venous thromboembolism ( 25772935 28373160 31420334 31676865)
Interacting Genes			5 interacting genes: BTRC GYPC RGS2 STRIT1 SYNE4
Entrez ID		1116	23555
HPRD ID		03314	15511
Ensembl ID		ENSG00000133048	ENSG00000099282
Uniprot IDs		P36222	O95858
PDB IDs		1HJV 1HJW 1HJX 1NWR 1NWS 1NWT 1NWU 7CJ2 8DF1 8R41 8R42 8R4X	7RD5 7RDB 8ESV
Enriched GO Terms of Interacting Partners?		Tetraspanin-enriched Microdomain Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Notch Signaling Pathway
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