ERP29 and IFT81

		ERP29	IFT81
Description		endoplasmic reticulum protein 29	intraflagellar transport 81
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Cell Surface Membrane Melanosome	Cytoplasm Centrosome Centriole Microtubule Organizing Center Cytoskeleton Cilium Intraciliary Transport Particle B Motile Cilium Ciliary Basal Body Cell Projection Sperm Midpiece Sperm Principal Piece Ciliary Tip
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein Homodimerization Activity Protein-folding Chaperone Binding	Protein Binding Tubulin Binding
	Biological Process	Protein Folding Intracellular Protein Transport Protein Secretion Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Protein Unfolding Positive Regulation Of MAPK Cascade Negative Regulation Of Protein Secretion Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway	Spermatogenesis Regulation Of Smoothened Signaling Pathway Cell Projection Organization Cell Differentiation Intraciliary Anterograde Transport Intraciliary Transport Involved In Cilium Assembly Intraciliary Transport Cilium Assembly Sperm Flagellum Assembly
Pathways			Intraflagellar transport Intraflagellar transport
Drugs
Diseases
GWAS		Body mass index ( 26426971) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Headache ( 29397368) Intelligence (MTAG) ( 29326435) Total intracranial volume ( 31530798)
Interacting Genes		21 interacting genes: ADIPOQ BMP10 C3orf52 CEBPA CTNNBL1 DESI1 GLP1R HMG20B HSPA5 NRM PUF60 SGTA SGTB SLC35B4 SLC38A7 TMBIM6 TMEM86B TSPO2 UBQLN1 UBQLN2 UBQLN4	2 interacting genes: APP HUNK
Entrez ID		10961	28981
HPRD ID		03794	09266
Ensembl ID		ENSG00000089248	ENSG00000122970
Uniprot IDs		P30040 V9HW71	Q8WYA0
PDB IDs		2QC7 5V8Z 5V90
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Positive Regulation Of ERAD Pathway Regulation Of Protein Catabolic Process Regulation Of Proteolysis ERAD Pathway Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteasomal Protein Catabolic Process Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Identical Protein Binding Negative Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Response To Endoplasmic Reticulum Stress Post-translational Protein Targeting To Membrane, Translocation Regulation Of Cellular Response To Stress Regulation Of Protein Metabolic Process Endoplasmic Reticulum Regulation Of Ubiquitin-dependent Protein Catabolic Process IRE1-mediated Unfolded Protein Response Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Autophagosome Regulation Of IRE1-mediated Unfolded Protein Response Protein-containing Complex Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cellular Localization Positive Regulation Of Protein Metabolic Process Autophagy Brown Fat Cell Differentiation Protein Targeting To ER Intracellular Protein Transmembrane Transport Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Establishment Of Protein Localization To Endoplasmic Reticulum RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Integrated Stress Response Signaling Glucagon-like Peptide 1 Receptor Activity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Folding In Endoplasmic Reticulum Negative Regulation Of Calcium Ion Transmembrane Transport Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Store-operated Calcium Channel Activity	Protein Homodimerization Activity Acetylcholine Receptor Activator Activity Protein-folding Chaperone Binding Amyloid-beta Complex PTB Domain Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Regulation Of Response To Calcium Ion Regulation Of Establishment Of Protein Localization Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Lymphocyte Migration Lipoprotein Particle Regulation Of Protein Transport Growth Factor Receptor Binding Main Axon Regulation Of Mononuclear Cell Migration Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Dendritic Spine Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Regulation Of Secretion Regulation Of Secretion By Cell L-serine Ammonia-lyase Activity Threonine Deaminase Activity L-serine Catabolic Process Pyruvate Biosynthetic Process Sodium Ion Transmembrane Transport Intracellularly Phosphatidylinositol-3,5-bisphosphate-gated Monatomic Cation Channel Activity Voltage-gated Channel Activity NAADP-sensitive Calcium-release Channel Activity NatB Complex Calcium:sodium Antiporter Activity Involved In Regulation Of Cardiac Muscle Cell Membrane Potential Calcium:sodium Antiporter Activity Calcium:monoatomic Cation Antiporter Activity
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