OS9 and ACP1

		OS9	ACP1
Description		OS9 endoplasmic reticulum lectin	acid phosphatase 1
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GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane	Cytoplasm Cytosol Cytoplasmic Side Of Plasma Membrane Sarcolemma Synapse Extracellular Exosome
	Molecular Function	Protease Binding Protein Binding Carbohydrate Binding Glycosylation-dependent Protein Binding	Acid Phosphatase Activity Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity SH3 Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Intracellular Protein Localization Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Chemical Synaptic Transmission
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs			Adenine 4-Nitrophenyl Phosphate
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)	Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Large artery stroke ( 28265093) Night sleep phenotypes ( 27126917) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 USP40 ZNF512B	16 interacting genes: BARD1 CTNNB1 EPHA2 EPHB1 EPHB2 ERBB2 FABP4 FNBP1L FYN INSR KDR LCK MRPL20 SFMBT1 SPTAN1 ZAP70
Entrez ID		10956	52
HPRD ID		17804	08881
Ensembl ID		ENSG00000135506	ENSG00000143727
Uniprot IDs		A0A8V8TPZ4 A0A8V8TQI8 A0A8V8TR34 Q13438	A0A140VK37 P24666 Q59EH3
PDB IDs		3AIH	1XWW 3N8I 4Z99 4Z9A 4Z9B 5JNR 5JNS 5JNT 5KQG 5KQL 5KQM 5KQP 5PNT 6Y2V 6Y2W 7KH8 7UW6
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ossification L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity Regulation Of Ossification Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Oxygen Homeostasis Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Nodal Signaling Pathway I-SMAD Binding Regulation Of MiRNA Transcription Peptide Hormone Secretion Regulation Of Macroautophagy Peptide Secretion Dioxygenase Activity Protein Hydroxylation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of Bone Mineralization 2-oxoglutarate-dependent Dioxygenase Activity Hormone Secretion Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Hormone Transport Peptide Transport Ferrous Iron Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Neuron Apoptotic Process Iron Ion Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Erythrocyte Differentiation Activin Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hypoxia Response To Decreased Oxygen Levels Regulation Of Apoptotic Process Response To Hypoxia Negative Regulation Of Biomineral Tissue Development Assembly Of Large Subunit Precursor Of Preribosome D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Monoatomic Cation Channel Activity Positive Regulation Of Protein-containing Complex Disassembly Lytic Vacuole Monocyte Activation Involved In Immune Response Positive Regulation Of Deacetylase Activity Osmosensor Activity	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Kinase Activity Protein Phosphorylation Phosphorylation Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MAPK Cascade Dendritic Spine Organization Protein Modification Process Neuron Projection Organization Postsynapse Organization Regulation Of Multicellular Organismal Development Ephrin Receptor Signaling Pathway Ephrin Receptor Activity Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Response To Growth Factor Phosphatidylinositol 3-kinase Binding Cell Migration Transferase Activity Protein Metabolic Process Regulation Of Multicellular Organismal Process Cell Activation Phosphate-containing Compound Metabolic Process Membrane Raft ATP Binding Regulation Of Developmental Process Cell Motility Positive Regulation Of MAPK Cascade Positive Regulation Of Cell Junction Assembly Lymphocyte Activation Cell Surface Receptor Signaling Pathway Regulation Of Cell Junction Assembly Positive Regulation Of Cellular Component Organization Protein Autophosphorylation CD8 Receptor Binding Positive Regulation Of Cell Adhesion Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Animal Organ Morphogenesis T Cell Activation Optic Nerve Morphogenesis Hindbrain Tangential Cell Migration Non-membrane Spanning Protein Tyrosine Kinase Activity Cadherin Binding
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