OS9 and P3H3

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)

		OS9	P3H3
Description		OS9 endoplasmic reticulum lectin	prolyl 3-hydroxylase 3
Image			No pdb structure
GO Annotations	Cellular Component	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Catalytic Complex
	Molecular Function	Protease Binding Protein Binding Carbohydrate Binding Glycosylation-dependent Protein Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Procollagen-proline 3-dioxygenase Activity L-ascorbic Acid Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Intracellular Protein Localization Protein Ubiquitination Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress ERAD Pathway Negative Regulation Of Retrograde Protein Transport, ER To Cytosol	Negative Regulation Of Cell Population Proliferation Peptidyl-lysine Hydroxylation Collagen Metabolic Process Collagen Biosynthetic Process
Pathways		ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)	Collagen biosynthesis and modifying enzymes
Drugs			Ascorbic acid Proline
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 USP40 ZNF512B	6 interacting genes: KRT31 KRTAP1-3 KRTAP12-3 KRTAP9-2 TRIM55 TRIM63
Entrez ID		10956	10536
HPRD ID		17804	10039
Ensembl ID		ENSG00000135506	ENSG00000110811
Uniprot IDs		A0A8V8TPZ4 A0A8V8TQI8 A0A8V8TR34 Q13438	Q8IVL6
PDB IDs		3AIH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Ossification L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity Hypoxia-inducible Factor-proline Dioxygenase Activity Regulation Of Ossification Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Oxygen Homeostasis Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Nodal Signaling Pathway I-SMAD Binding Regulation Of MiRNA Transcription Peptide Hormone Secretion Regulation Of Macroautophagy Peptide Secretion Dioxygenase Activity Protein Hydroxylation Regulation Of Myeloid Cell Differentiation Regulation Of MiRNA Metabolic Process Negative Regulation Of Bone Mineralization 2-oxoglutarate-dependent Dioxygenase Activity Hormone Secretion Cellular Response To Stress Positive Regulation Of Transcription By RNA Polymerase II Hormone Transport Peptide Transport Ferrous Iron Binding Positive Regulation Of Myeloid Cell Differentiation Regulation Of Neuron Apoptotic Process Iron Ion Binding Negative Regulation Of MiRNA Transcription Positive Regulation Of Erythrocyte Differentiation Activin Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Hypoxia Response To Decreased Oxygen Levels Regulation Of Apoptotic Process Response To Hypoxia Negative Regulation Of Biomineral Tissue Development Assembly Of Large Subunit Precursor Of Preribosome D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Type 1 Parathyroid Hormone Receptor Binding Parathyroid Hormone Receptor Binding Monoatomic Cation Channel Activity Positive Regulation Of Protein-containing Complex Disassembly Lytic Vacuole Monocyte Activation Involved In Immune Response Positive Regulation Of Deacetylase Activity Osmosensor Activity	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Glycosylation-dependent Protein Binding Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Retention In ER Lumen Protein Modification By Small Protein Conjugation Hrd1p Ubiquitin Ligase Complex Protein Ubiquitination Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Post-translational Protein Modification Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Muscle Atrophy
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