STARD3 and RNF170

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		STARD3	RNF170
Description		StAR related lipid transfer domain containing 3	ring finger protein 170
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Membrane Cytosol Membrane Late Endosome Membrane Organelle Membrane Contact Site Endoplasmic Reticulum-endosome Membrane Contact Site	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Lipid Binding Cholesterol Binding Protein Homodimerization Activity Cholesterol Transfer Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Progesterone Biosynthetic Process Mitochondrial Transport Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Small Molecule Metabolic Process Vesicle Tethering To Endoplasmic Reticulum	Protein Polyubiquitination Adult Walking Behavior Response To Temperature Stimulus Gene Expression Proteasomal Protein Catabolic Process Response To Activity Protein Ubiquitination Protein Catabolic Process Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Protein K48-linked Ubiquitination Walking Behavior
Pathways		Pregnenolone biosynthesis
Drugs
Diseases
GWAS		Alcohol consumption ( 31358974) Apolipoprotein A1 levels ( 32203549) Asthma ( 31959851 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) HDL cholesterol ( 20686565 24097068) HDL cholesterol levels ( 32203549 28334899 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) Hemoglobin levels ( 32327693) Menopause (age at onset) ( 26414677) Pancreatic ductal adenocarcinoma ( 30541042) Refractive error ( 32231278) Smoking behaviour (cigarettes smoked per day) ( 30679032) Triglyceride levels ( 30108155) Ulcerative colitis ( 20228799)
Interacting Genes		9 interacting genes: AQP6 CREB3 DAPK1 GOPC LMNA MOSPD2 RNF170 VAPA VAPB	15 interacting genes: DNAJC30 FXYD6-FXYD2 HACD1 PLPP6 PSMA6 SGTA SGTB SNAP47 STARD3 TMEM109 TMEM97 UBE2D2 UBE2L3 UBE2U UPK2
Entrez ID		10948	81790
HPRD ID		06132	13165
Ensembl ID		ENSG00000131748	ENSG00000120925
Uniprot IDs		Q14849	Q96K19
PDB IDs		1EM2 5I9J 6TQR 6TQU
Enriched GO Terms of Interacting Partners?		FFAT Motif Binding COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Endoplasmic Reticulum Localization Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Endoplasmic Reticulum Membrane Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Monocyte Chemotaxis Intracellular Transport Viral Release From Host Cell Viral Process Endoplasmic Reticulum Exit Site Regulation Of Monocyte Chemotaxis Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process Nitrate Transmembrane Transporter Activity DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Cellular Localization Establishment Of Localization In Cell Polychlorinated Biphenyl Binding Endoplasmic Reticulum Positive Regulation Of Deacetylase Activity Negative Regulation Of Anion Channel Activity Endoplasmic Reticulum Organization Nuclear Membrane Cholesterol Transport Endoplasmic Reticulum Unfolded Protein Response Golgi Vesicle Transport PH-gated Chloride Channel Activity Nitrate Transmembrane Transport DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Negative Regulation By Virus Of Viral Protein Levels In Host Cell Host-mediated Perturbation Of Viral Process Sterol Transport Organelle Localization By Membrane Tethering Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Response To Unfolded Protein Membrane Docking Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Mononuclear Cell Migration Regulation Of NMDA Receptor Activity Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Response To Ozone Response To Silicon Dioxide	TRC Complex Ubiquitin Conjugating Enzyme Activity Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-like Protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Purine Ribonucleoside Triphosphate Binding Establishment Of Protein Localization To Membrane Protein Targeting Cholesterol Binding Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process
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