MAGED2 and KDM6A

		MAGED2	KDM6A
Description		MAGE family member D2	lysine demethylase 6A
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytosol Membrane Platelet Alpha Granule Lumen	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Oxidoreductase Activity Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K27me2/H3K27me3 Demethylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Female Pregnancy Renal Sodium Ion Absorption	Chromatin Organization Chromatin Remodeling Heart Development Regulation Of Gene Expression
Pathways		Platelet degranulation	HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis Formation of WDR5-containing histone-modifying complexes Epigenetic regulation of gene expression by MLL3 and MLL4 complexes Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs
Diseases
GWAS
Interacting Genes		4 interacting genes: CHRM3 EEF1A1 PTEN WEE2-AS1	15 interacting genes: CREBBP GSC2 H3-4 H3C1 H3C14 HUNK MEOX2 MTDH NKX2-5 RSPH1 SMAD9 SRF TBX5 TLE1 TSPYL2
Entrez ID		10916	7403
HPRD ID		06630	02131
Ensembl ID		ENSG00000102316	ENSG00000147050
Uniprot IDs		Q9UNF1	A0A087X0R0 A0A6Q8PFK0 A0A804HJA2 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3
PDB IDs			3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?		Acetylcholine Binding Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Trans-synaptic Signaling Saliva Secretion Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Activity Chemical Synaptic Transmission Kinase Activator Activity Host-mediated Perturbation Of Viral Genome Replication Eukaryotic Translation Elongation Factor 1 Complex Cytoplasmic Side Of Lysosomal Membrane Host-mediated Activation Of Viral Genome Replication Regulation Of Chaperone-mediated Autophagy Locomotor Rhythm Negative Regulation Of Synaptic Vesicle Clustering Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Myelin Sheath Adaxonal Region Cellular Response To Electrical Stimulus Ubiquitin Ligase Activator Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Spindle Assembly Involved In Female Meiosis Negative Regulation Of Keratinocyte Migration Inositol-1,3,4,5-tetrakisphosphate 3-phosphatase Activity Negative Regulation Of Peptidyl-serine Phosphorylation Regulation Of Synaptic Vesicle Clustering Postsynaptic Specialization Assembly Negative Regulation Of Wound Healing, Spreading Of Epidermal Cells Neuron-neuron Synaptic Transmission Phosphatidylinositol Phosphate Phosphatase Activity Central Nervous System Myelin Maintenance Negative Regulation Of Cell Size Maternal Behavior Presynaptic Membrane Organization Schmidt-Lanterman Incisure Heart Development Rhythmic Synaptic Transmission Anaphase-promoting Complex Binding Postsynaptic Density Assembly Forebrain Morphogenesis Negative Regulation Of Excitatory Postsynaptic Potential Presynaptic Membrane Assembly Inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase Activity Histone H3K27me2/H3K27me3 Demethylase Activity MLL3/4 Complex Pre-mRNA 5'-splice Site Binding MRNA 5'-splice Site Recognition Synaptic Signaling Phosphatidylinositol-3-phosphate Phosphatase Activity Prepulse Inhibition Meiotic Spindle Assembly	RNA Polymerase II-specific DNA-binding Transcription Factor Binding Chromatin Atrioventricular Node Cell Fate Commitment Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus His-Purkinje System Cell Differentiation Regulation Of RNA Metabolic Process Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Regulator Complex Nucleosome Assembly DNA-binding Transcription Factor Activity DNA Binding Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Chromatin Binding Regulation Of RNA Biosynthetic Process Nucleosome Organization Cardiocyte Differentiation Muscle Tissue Development Cardiac Muscle Cell Fate Commitment Cardiac Ventricle Formation Atrial Septum Development Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Cardiac Chamber Formation Protein-DNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Atrial Cardiac Muscle Tissue Development Ventricular Cardiac Muscle Tissue Development Regulation Of Primary Metabolic Process Muscle Cell Fate Commitment Heart Trabecula Formation Positive Regulation Of Cardiocyte Differentiation RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cardiac Myofibril Assembly Structural Constituent Of Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Atrial Septum Morphogenesis Epithelium Development Positive Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Nucleoplasm Regulation Of Metabolic Process Cellular Component Assembly Muscle Cell Differentiation Positive Regulation Of Stem Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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