NMU and NMUR2

Number of citations of the paper that reports this interaction (PubMedID 10899166)
0

Data Source:
HPRD (in vitro, in vivo)

		NMU	NMUR2
Description		neuromedin U	neuromedin U receptor 2
Image
GO Annotations	Cellular Component	Extracellular Region Terminal Bouton	Plasma Membrane Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Type 1 Neuromedin U Receptor Binding Type 2 Neuromedin U Receptor Binding Neuromedin U Receptor Binding	Neuromedin U Receptor Activity G Protein-coupled Receptor Activity Intracellularly Calcium-gated Chloride Channel Activity Protein Binding GTP Binding Neuropeptide Receptor Activity Neuromedin U Binding
	Biological Process	Temperature Homeostasis Gastric Acid Secretion Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Photoperiodism Positive Regulation Of Heart Rate Positive Regulation Of Heat Generation Eating Behavior Regulation Of Circadian Sleep/wake Cycle, Sleep Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Positive Regulation Of Synaptic Transmission Regulation Of Feeding Behavior Negative Regulation Of Gastric Acid Secretion Energy Homeostasis Negative Regulation Of Gastric Emptying Positive Regulation Of Stomach Fundus Smooth Muscle Contraction Positive Regulation Of Prolactin Secretion Negative Regulation Of Eating Behavior Positive Regulation Of Sensory Perception Of Pain Negative Regulation Of Feeding Behavior Regulation Of Grooming Behavior	Reduction Of Food Intake In Response To Dietary Excess Chloride Transport Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Central Nervous System Development Grooming Behavior Feeding Behavior Response To Pain Arachidonate Secretion Positive Regulation Of Calcium-mediated Signaling Chloride Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Subcortical volume (MOSTest) ( 32665545) Urinary albumin excretion ( 30220432 32277301) Urinary albumin-to-creatinine ratio ( 31511532 31630189) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172 26426971) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412)	Ability to confide in someone ( 29970889) Adult body size ( 32376654) Bipolar disorder ( 33169155) Bipolar disorder and schizophrenia ( 22688191) Body size at age 10 ( 32376654) Caffeine consumption from tea ( 33287642) Chronotype ( 30696823) Feeling lonely ( 29500382) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Manganese levels ( 26025379) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Optic nerve measurement (cup area) ( 20395239) Periodontitis (PAL4Q3) ( 24024966) Schizophrenia ( 28991256) Sedentary behaviour duration ( 30531941) Subjective well-being ( 27089181)
Interacting Genes		16 interacting genes: CYSRT1 DCDC2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-6 KRTAP12-3 KRTAP17-1 KRTAP5-9 NBPF19 NMUR1 NMUR2 NOTCH2NLA SNTA1 TNS2	6 interacting genes: ADAMTSL4 KRTAP13-1 NMU NOTCH2NLA TCF4 TRAF2
Entrez ID		10874	56923
HPRD ID		05485	12003
Ensembl ID		ENSG00000109255	ENSG00000132911
Uniprot IDs		A0A0B4J202 A0A250SH36 E9PDJ7 P48645 Q86WB6	Q9GZQ4
PDB IDs		7W53 7W55 7XK8	7W55 7W57 7XK8
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Neuromedin U Receptor Activity Neuromedin U Binding Neuropeptide Receptor Activity Epidermis Development Structural Constituent Of Skin Epidermis Positive Regulation Of Calcium-mediated Signaling	TORC2 Complex Disassembly Neuromedin U Receptor Binding Type 2 Neuromedin U Receptor Binding Negative Regulation Of Gastric Emptying Positive Regulation Of Stomach Fundus Smooth Muscle Contraction Type 1 Neuromedin U Receptor Binding Pigment Cell Development TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Positive Regulation Of Prolactin Secretion TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Sensory Perception Of Pain Regulation Of Gastric Motility Regulation Of Grooming Behavior Negative Regulation Of Eating Behavior CD27 Signaling Pathway Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of Gastric Acid Secretion Negative Regulation Of Feeding Behavior Interstitial Matrix Regulation Of Eating Behavior Gastric Acid Secretion Thioesterase Binding CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of Heat Generation Positive Regulation Of JUN Kinase Activity Beta-catenin-TCF Complex TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Positive Regulation Of Systemic Arterial Blood Pressure Cellular Response To Reactive Nitrogen Species
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