NMU and NMUR2

Number of citations of the paper that reports this interaction (PMID 10894543)
33

Data Source:
HPRD (in vitro, in vivo)

		NMU	NMUR2
Gene Name		neuromedin U	neuromedin U receptor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Terminal Bouton	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Binding Neuromedin U Receptor Binding	Neuromedin U Receptor Activity G-protein Coupled Receptor Activity Intracellular Calcium Activated Chloride Channel Activity GTP Binding Neuromedin U Binding
	Biological Process	Gastric Acid Secretion Regulation Of Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Digestion Photoperiodism Sensory Perception Of Pain Eating Behavior Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Hormone Secretion Positive Regulation Of Synaptic Transmission	Reduction Of Food Intake In Response To Dietary Excess Calcium Ion Transport Chloride Transport Regulation Of Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Central Nervous System Development Grooming Behavior Feeding Behavior Calcium-mediated Signaling Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Inositol Phosphate-mediated Signaling Response To Pain Arachidonic Acid Secretion Chloride Transmembrane Transport
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS			Bipolar disorder and schizophrenia ( 22688191) Optic disc size (cup) ( 20395239)
Protein-Protein Interactions		5 interactors: KRTAP5-9 NMUR1 NMUR2 NOTCH2NL SNTA1	6 interactors: ADAMTSL4 KRTAP13-1 NMU NOTCH2NL TCF4 TRAF2
Entrez ID		10874	56923
HPRD ID		05485	12003
Ensembl ID		ENSG00000109255	ENSG00000132911
Uniprot IDs		P48645	Q9GZQ4
PDB IDs
Enriched GO Terms of Interacting Partners?		Inositol Phosphate-mediated Signaling Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Calcium-mediated Signaling Neuropeptide Signaling Pathway Regulation Of Vasoconstriction By Circulating Norepinephrine Chloride Transport Second-messenger-mediated Signaling Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Regulation Of Muscle Contraction Reduction Of Food Intake In Response To Dietary Excess Activation Of Phospholipase A2 Activity Muscle Contraction Negative Regulation Of Peptidyl-cysteine S-nitrosylation Positive Regulation Of Phospholipase A2 Activity Inorganic Anion Transport Muscle System Process Calcium Ion Transport Regulation Of Phospholipase A2 Activity Arachidonic Acid Secretion Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Response To Dietary Excess Grooming Behavior Ventricular Cardiac Muscle Cell Action Potential Regulation Of Membrane Repolarization Synaptic Transmission Cardiac Muscle Cell Action Potential Involved In Contraction Eating Behavior Anion Transport Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Response To Pain Long-chain Fatty Acid Transport Regulation Of Cardiac Muscle Cell Contraction Activation Of Phospholipase C Activity Neuromuscular Junction Development Regulation Of Smooth Muscle Contraction Metal Ion Transport Positive Regulation Of Phospholipase C Activity Regulation Of Vasoconstriction Acid Secretion Smooth Muscle Contraction Fatty Acid Transport Cell-cell Signaling Regulation Of Sodium Ion Transport Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Positive Regulation Of Hydrolase Activity	Positive Regulation Of Protein Binding Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Secretion Positive Regulation Of Hormone Secretion Positive Regulation Of Binding Regulation Of Protein Binding Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cellular Localization Maintenance Of DNA Repeat Elements Regulation Of Binding Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Regulation Of Hormone Secretion Embryonic Genitalia Morphogenesis Negative Regulation Of Glial Cell Apoptotic Process Cell Surface Receptor Signaling Pathway Myoblast Fate Commitment Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Secretion Secretory Granule Localization Positive Regulation Of Protein Homodimerization Activity Regulation Of Apoptotic Process Hindgut Morphogenesis Protein O-linked Fucosylation Gastric Acid Secretion Cellular Response To Nitric Oxide Insulin Metabolic Process Regulation Of Cell Death Regulation Of Immunoglobulin Secretion Hindgut Development Regulation Of Protein Secretion Response To Nitric Oxide Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Glycoprotein Metabolic Process Positive Regulation Of Gluconeogenesis Protein Homotrimerization Positive Regulation Of T Cell Cytokine Production Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Regulation Of Protein Homodimerization Activity Cellular Response To Reactive Nitrogen Species Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of T Cell Cytokine Production
Tagcloud ?		alter animals burden carcinogen content dawley estrogen exercise exercised exercising experiment final grams hypothesized incline latency microg multiplicity overshadowed prior progressive pronounced saturated sedentary sets sprague terminated treadmill workload	alongside arcuate crapb1 crbp1 cyp26b1 ependymal f344 fall hypothalamus injections mammals melatonin neuroendocrine nutrient photoperiod photoperiodic player players probable ra raldh1 rpe65 seasonal stra6 th ttr ventricle vitamin
Tagcloud (Difference) ?		alter animals burden carcinogen content dawley estrogen exercise exercised exercising experiment final grams hypothesized incline latency microg multiplicity overshadowed prior progressive pronounced saturated sedentary sets sprague terminated treadmill workload	alongside arcuate crapb1 crbp1 cyp26b1 ependymal f344 fall hypothalamus injections mammals melatonin neuroendocrine nutrient photoperiod photoperiodic player players probable ra raldh1 rpe65 seasonal stra6 th ttr ventricle vitamin
Tagcloud (Intersection) ?