NMUR2

Description		neuromedin U receptor 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane
	Molecular Function	Neuromedin U Receptor Activity G Protein-coupled Receptor Activity Intracellularly Calcium-gated Chloride Channel Activity Protein Binding GTP Binding Neuropeptide Receptor Activity Neuromedin U Binding
	Biological Process	Reduction Of Food Intake In Response To Dietary Excess Chloride Transport Regulation Of Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Cell-cell Signaling Central Nervous System Development Grooming Behavior Feeding Behavior Response To Pain Arachidonate Secretion Positive Regulation Of Calcium-mediated Signaling Chloride Transmembrane Transport
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Ability to confide in someone ( 29970889) Adult body size ( 32376654) Bipolar disorder ( 33169155) Bipolar disorder and schizophrenia ( 22688191) Body size at age 10 ( 32376654) Caffeine consumption from tea ( 33287642) Chronotype ( 30696823) Feeling lonely ( 29500382) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Manganese levels ( 26025379) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Optic nerve measurement (cup area) ( 20395239) Periodontitis (PAL4Q3) ( 24024966) Schizophrenia ( 28991256) Sedentary behaviour duration ( 30531941) Subjective well-being ( 27089181)
Interacting Genes		6 interacting genes: ADAMTSL4 KRTAP13-1 NMU NOTCH2NLA TCF4 TRAF2
Entrez ID		56923
HPRD ID		12003
Ensembl ID		ENSG00000132911
Uniprot IDs		Q9GZQ4
PDB IDs		7W55 7W57 7XK8
Enriched GO Terms of Interacting Partners?		TORC2 Complex Disassembly Neuromedin U Receptor Binding Type 2 Neuromedin U Receptor Binding Negative Regulation Of Gastric Emptying Positive Regulation Of Stomach Fundus Smooth Muscle Contraction Type 1 Neuromedin U Receptor Binding Pigment Cell Development TRAF2-GSTP1 Complex TORC1 Complex Assembly CD40 Receptor Binding Positive Regulation Of Prolactin Secretion TFIIB-class Transcription Factor Binding Beta-catenin-TCF7L2 Complex Sphingolipid Binding IRE1-TRAF2-ASK1 Complex Tumor Necrosis Factor Receptor Superfamily Complex Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Sensory Perception Of Pain Regulation Of Gastric Motility Regulation Of Grooming Behavior Negative Regulation Of Eating Behavior CD27 Signaling Pathway Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Tumor Necrosis Factor Binding Tumor Necrosis Factor Receptor Superfamily Binding Regulation Of Gastric Acid Secretion Negative Regulation Of Feeding Behavior Interstitial Matrix Regulation Of Eating Behavior Gastric Acid Secretion Thioesterase Binding CD40 Signaling Pathway Negative Regulation Of Glial Cell Apoptotic Process Interleukin-17-mediated Signaling Pathway CD40 Receptor Complex Positive Regulation Of Heat Generation Positive Regulation Of JUN Kinase Activity Beta-catenin-TCF Complex TORC2 Signaling Cellular Response To Nitric Oxide Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Mitogen-activated Protein Kinase Kinase Kinase Binding Positive Regulation Of Systemic Arterial Blood Pressure Cellular Response To Reactive Nitrogen Species
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