ZNF273 and SP8

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		ZNF273	SP8
Description		zinc finger protein 273	Sp8 transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Embryonic Limb Morphogenesis
Pathways		Generic Transcription Pathway Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Triglyceride levels x short total sleep time interaction (1df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535)	Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Bipolar I disorder ( 20386566) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Prostate cancer ( 23535732) Response to statin therapy ( 20339536) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		3 interacting genes: CA14 KRTAP10-5 SP8	3 interacting genes: HEYL ZNF273 ZNF519
Entrez ID		10793	221833
HPRD ID		07264	12208
Ensembl ID		ENSG00000198039	ENSG00000164651
Uniprot IDs		Q14593	A8K350 Q8IXZ3
PDB IDs
Enriched GO Terms of Interacting Partners?			DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding AF-1 Domain Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Transcription By RNA Polymerase II Aortic Valve Morphogenesis Glomerulus Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Atrioventricular Valve Morphogenesis Mesenchymal Cell Development Cellular Response To BMP Stimulus Pulmonary Valve Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Nephron Tubule Development Renal Tubule Development Proximal Tubule Development Cardiac Ventricle Morphogenesis Regulation Of Androgen Receptor Signaling Pathway Endocardial Cushion Morphogenesis Circulatory System Development Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Ventricular Septum Morphogenesis Regulation Of RNA Metabolic Process Heart Valve Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Skeletal Muscle Cell Differentiation Outflow Tract Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Kidney Epithelium Development Cardiac Septum Morphogenesis
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