SLC12A7 and GPR61

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC12A7	GPR61
Description		solute carrier family 12 member 7	G protein-coupled receptor 61
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Synapse	Endosome Plasma Membrane Endosome Membrane Membrane Receptor Complex
	Molecular Function	Protein Binding Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity	G Protein-coupled Receptor Activity Protein Binding Arrestin Family Protein Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Signal Transduction G Protein-coupled Receptor Signaling Pathway Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Cation-coupled Chloride cotransporters
Drugs		Potassium chloride
Diseases
GWAS		Granulocyte count ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) JT interval ( 29874175) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 20139978 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Pancreatic cancer ( 25086665) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Weight ( 28552196) White blood cell count ( 32888494)	Adult body size ( 32376654) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Childhood body mass index ( 26604143) Chronotype ( 30696823) Hepcidin/ferritin ratio ( 27846281) Morning person ( 30696823) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Stearic acid (18:0) levels ( 23362303) Waist circumference ( 25673412)
Interacting Genes		14 interacting genes: GJB1 GPR61 MS4A13 OPRD1 OTP SERINC2 SLC10A1 SLC10A6 SLC35H1 TMBIM6 TMEM147 TMEM237 TMEM54 YIPF6	20 interacting genes: APP ARL6IP6 ARLN ATP6V0B CLDND1 CTXN3 EMP3 FCER1G GJA8 GJB6 KLRC1 PLP1 PMP22 SCN3B SLC12A7 SLC13A4 STRIT1 TMEM147 TMEM218 TRARG1
Entrez ID		10723	83873
HPRD ID		09221	06077
Ensembl ID		ENSG00000113504	ENSG00000156097
Uniprot IDs		Q9Y666	G4XH66 Q9BZJ8
PDB IDs		7D99	8KGK 8TB0 8TB7
Enriched GO Terms of Interacting Partners?		Bile Acid:sodium Symporter Activity Membrane Bile Acid And Bile Salt Transport Plasma Membrane G Protein-coupled Enkephalin Receptor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cis-Golgi Network Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Membrane Plasma Membrane Gap Junction-mediated Intercellular Transport Cell-cell Signaling Signaling Bleb Assembly Intercellular Transport Cell Communication Transmembrane Transport Connexin Complex Gap Junction Channel Activity Chemical Synaptic Transmission Protein Localization To Membrane Gap Junction Trans-synaptic Signaling Synaptic Signaling
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?