SLC12A7 and SERINC2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC12A7	SERINC2
Description		solute carrier family 12 member 7	serine incorporator 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Protein-containing Complex Synapse	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding Symporter Activity Chloride:monoatomic Cation Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding Transmembrane Transporter Activity	Acetyltransferase Activator Activity Phospholipid Scramblase Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Cell Volume Homeostasis Chemical Synaptic Transmission Chloride Ion Homeostasis Potassium Ion Homeostasis Transmembrane Transport Cellular Response To Glucose Stimulus Potassium Ion Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Phosphatidylserine Metabolic Process Plasma Membrane Phospholipid Scrambling
Pathways		Cation-coupled Chloride cotransporters	Serine metabolism
Drugs		Potassium chloride
Diseases
GWAS		Granulocyte count ( 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte percentage of red cells ( 32888494) JT interval ( 29874175) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 20139978 29403010 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Pancreatic cancer ( 25086665) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) PR interval ( 32439900) Red blood cell count ( 27863252 32888494) Red cell distribution width ( 28957414 27863252 32888494) Reticulocyte fraction of red cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Weight ( 28552196) White blood cell count ( 32888494)	Alcohol dependence ( 23455491) Body mass index ( 26426971) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Heart rate response to recovery post exercise (50 sec) ( 29497042) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
Interacting Genes		14 interacting genes: GJB1 GPR61 MS4A13 OPRD1 OTP SERINC2 SLC10A1 SLC10A6 SLC35H1 TMBIM6 TMEM147 TMEM237 TMEM54 YIPF6	16 interacting genes: ARLN CCDC167 GPX8 LAT MFF SEC22B SLC12A7 SLC29A2 SLC39A9 SMAGP TMEM14A TMEM167B TMEM239 TMEM42 TMEM54 TMEM86B
Entrez ID		10723	347735
HPRD ID		09221	15481
Ensembl ID		ENSG00000113504	ENSG00000168528
Uniprot IDs		Q9Y666	Q96IM8 Q96SA4
PDB IDs		7D99
Enriched GO Terms of Interacting Partners?		Bile Acid:sodium Symporter Activity Membrane Bile Acid And Bile Salt Transport Plasma Membrane G Protein-coupled Enkephalin Receptor Activity Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cis-Golgi Network Ligand-independent Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport	Membrane
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