NPC2 and VASH1

		NPC2	VASH1
Description		NPC intracellular cholesterol transporter 2	vasohibin 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Apical Part Of Cell
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Actin Binding Carboxypeptidase Activity Metallocarboxypeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Tubulin-tyrosine Carboxypeptidase
	Biological Process	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Response To Virus Gene Expression Cholesterol Storage Phospholipid Transport Sterol Transport Sterol Metabolic Process Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport	Angiogenesis Negative Regulation Of Endothelial Cell Proliferation Proteolysis Response To Wounding Negative Regulation Of Angiogenesis Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Angiogenesis Regulation Of Cell Cycle Placenta Blood Vessel Development Labyrinthine Layer Blood Vessel Development Negative Regulation Of Lymphangiogenesis Regulation Of Cellular Senescence
Pathways		Neutrophil degranulation LDL clearance	Carboxyterminal post-translational modifications of tubulin
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Intraocular pressure ( 31959993) Refractive error ( 32231278) Soluble receptor for advanced glycation end-product levels ( 26915486)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	1 interacting genes: DHPS
Entrez ID		10577	22846
HPRD ID		03008	12353
Ensembl ID		ENSG00000119655	ENSG00000071246
Uniprot IDs		A0A024R6C0 G3V3E8 P61916	Q7L8A9
PDB IDs		5KWY 6W5V	6J4U 6J7B 6J8F 6J8N 6J8O 6J91 6J9H 6K81 6LPG 6NVQ 6OCF 6OCG 6OCH 6WSL
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Response To Ionizing Radiation Cellular Response To Ionizing Radiation BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Cellular Response To Radiation Ubiquitin-modified Histone Reader Activity Response To Radiation DNA Strand Resection Involved In Replication Fork Processing DNA Recombination Response To Stress Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Macromolecule Metabolic Process Protein K6-linked Ubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Activity Condensed Chromosome Homologous Recombination Regulation Of Protein Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Integrated Proviral Latency Adenosine Receptor Binding Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Adipose Tissue Development Mitotic G2/M Transition Checkpoint Post-translational Protein Modification DNA Repair Establishment Of Viral Latency Protein K33-linked Ubiquitination Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate	Spermidine Catabolic Process Polyamine Catabolic Process Deoxyhypusine Synthase Activity Cholesterol Storage Regulation Of Isoprenoid Metabolic Process Spermidine Metabolic Process Glycolipid Transport Sterol Binding Chemical Homeostasis Polyamine Metabolic Process Cholesterol Transfer Activity Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Lipid Storage Intracellular Lipid Transport Homeostatic Process Cholesterol Binding Macromolecule Biosynthetic Process Biogenic Amine Metabolic Process Cholesterol Transport Amine Metabolic Process Phospholipid Transport Sterol Homeostasis Sterol Transport Azurophil Granule Lumen Lysosomal Lumen Carbohydrate Derivative Transport Cholesterol Homeostasis Positive Regulation Of T Cell Proliferation Cholesterol Metabolic Process Sterol Metabolic Process
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