NPC2 and CTSW

		NPC2	CTSW
Description		NPC intracellular cholesterol transporter 2	cathepsin W
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Lysosome Endoplasmic Reticulum Endomembrane System Membrane Platelet Dense Granule Lumen Intracellular Organelle Lumen
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Cholesterol Transfer Activity	Cysteine-type Endopeptidase Activity Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	Lipid Metabolic Process Lipid Transport Steroid Metabolic Process Cholesterol Metabolic Process Response To Virus Gene Expression Cholesterol Storage Phospholipid Transport Sterol Transport Sterol Metabolic Process Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Cholesterol Homeostasis Glycolipid Transport	Immune System Process Proteolysis Immune Response Proteolysis Involved In Protein Catabolic Process
Pathways		Neutrophil degranulation LDL clearance	Platelet degranulation
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Intraocular pressure ( 31959993) Refractive error ( 32231278) Soluble receptor for advanced glycation end-product levels ( 26915486)	Acne (severe) ( 24927181) Asthma ( 31959851) Inflammatory bowel disease ( 23128233) Monocyte count ( 32888494)
Interacting Genes		9 interacting genes: BARD1 BRCA1 DHDDS ECT2 ERRFI1 LIG4 PAXIP1 TRIM14 USP4	1 interacting genes: CREB3
Entrez ID		10577	1521
HPRD ID		03008	03840
Ensembl ID		ENSG00000119655	ENSG00000172543
Uniprot IDs		A0A024R6C0 G3V3E8 P61916	P56202
PDB IDs		5KWY 6W5V
Enriched GO Terms of Interacting Partners?		Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity Response To Ionizing Radiation Cellular Response To Ionizing Radiation BRCA1-BARD1 Complex BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex BRCA1-A Complex Cellular Response To Radiation Ubiquitin-modified Histone Reader Activity Response To Radiation DNA Strand Resection Involved In Replication Fork Processing DNA Recombination Response To Stress Cellular Response To Stress Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Damage Checkpoint Macromolecule Metabolic Process Protein K6-linked Ubiquitination Protein Metabolic Process Ubiquitin Protein Ligase Activity Condensed Chromosome Homologous Recombination Regulation Of Protein Metabolic Process Negative Regulation Of MRNA 3'-end Processing Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Establishment Of Integrated Proviral Latency Adenosine Receptor Binding Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding Polyprenol Biosynthetic Process Dehydrodolichyl Diphosphate Synthase Complex Ditrans,polycis-polyprenyl Diphosphate Synthase [(2E,6E)-farnesyl Diphosphate Specific] Activity Adipose Tissue Development Mitotic G2/M Transition Checkpoint Post-translational Protein Modification DNA Repair Establishment Of Viral Latency Protein K33-linked Ubiquitination Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate	Positive Regulation Of Deacetylase Activity Endoplasmic Reticulum CCR1 Chemokine Receptor Binding Release From Viral Latency Cholesterol Storage Sterol Binding Regulation Of Isoprenoid Metabolic Process Regulation Of Cell Growth Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Locomotion Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Growth Positive Regulation Of Cell Motility Induction Of Positive Chemotaxis CAMP Response Element Binding Protein Binding Positive Regulation Of Positive Chemotaxis Cholesterol Transfer Activity Intracellular Sterol Transport Glycolipid Transport Intracellular Cholesterol Transport Lysosome TORC2 Complex Enzyme-substrate Adaptor Activity TORC2 Signaling Regulation Of Establishment Of Cell Polarity Negative Regulation Of CGAS/STING Signaling Pathway Serine/threonine Protein Kinase Complex Regulation Of Establishment Or Maintenance Of Cell Polarity CGAS/STING Signaling Pathway Cholesterol Efflux Negative Regulation Of Intracellular Signal Transduction Regulation Of Monocyte Chemotaxis Lipid Storage Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Intracellular Lipid Transport Transcription Coregulator Binding Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Integrated Stress Response Signaling Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?