CEBPG and CEBPE

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CEBPG	CEBPE
Description		CCAAT enhancer binding protein gamma	CCAAT enhancer binding protein epsilon
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Plasma Membrane RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding Protein-containing Complex Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Liver Development DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Immune Response MRNA Metabolic Process B Cell Differentiation Positive Regulation Of Type II Interferon Production Natural Killer Cell Mediated Cytotoxicity Enucleate Erythrocyte Differentiation Positive Regulation Of DNA Binding Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA Repair Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Integrated Stress Response Signaling	DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Phagocytosis Defense Response Positive Regulation Of Gene Expression Myeloid Cell Differentiation Macrophage Differentiation Granulocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Integrated Stress Response Signaling
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency	Transcriptional regulation of granulopoiesis
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Inflammatory bowel disease ( 23128233) Pancreas fat ( 34128465) Schizophrenia ( 26198764) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 22076464 23512250 29348612 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) B-cell acute lymphoblastic leukaemia ( 31767839) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252 32888494 29403010) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252) White blood cell count (basophil) ( 29403010 28158719 27863252)
Interacting Genes		24 interacting genes: ATF2 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CEBPA CEBPB CEBPD CEBPE CREB3 CREB3L3 DBP DDIT3 FOS FOSL1 GTF2F2 JUN MLLT6 NFE2L2 PFDN6 PLAU POLR2M	45 interacting genes: ALX4 ATF3 ATF4 ATF5 BATF BATF2 BATF3 CCT7 CEBPA CEBPD CEBPG COPS3 CSNK1A1L DDIT3 DENND4A E2F1 EDA2R ELOB FOS FOSL1 GATA1 GPR22 GTF2A1L IL7 JUN KDM2B LDOC1 MED16 MLLT6 MYB NELFB PIAS1 POU2F1 PSAT1 RB1 SIPA1L1 SPI1 STAT6 TAF5L TBX2 TRIB1 UBE2I ZFP2 ZMYM2 ZNF384
Entrez ID		1054	1053
HPRD ID		00738	02852
Ensembl ID		ENSG00000153879	ENSG00000092067
Uniprot IDs		P53567	Q15744
PDB IDs			3T92
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Binding Positive Regulation Of RNA Metabolic Process Transcription Cis-regulatory Region Binding Intracellular Signaling Cassette Positive Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Positive Regulation Of Macromolecule Biosynthetic Process Cellular Response To Stress Positive Regulation Of Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Stress CAMP Response Element Binding Protein Binding Response To Endoplasmic Reticulum Stress RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Myeloid Leukocyte Differentiation CHOP-C/EBP Complex DNA-templated Transcription Mononuclear Cell Differentiation Macromolecule Biosynthetic Process Endoplasmic Reticulum Unfolded Protein Response Leukocyte Differentiation Myeloid Cell Differentiation Nucleobase-containing Compound Biosynthetic Process Sequence-specific DNA Binding Nucleus Response To Nutrient Levels Liver Development	RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Transcription Regulator Complex Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Nucleus Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of Macromolecule Biosynthetic Process Sequence-specific DNA Binding Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Negative Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Myeloid Leukocyte Differentiation Positive Regulation Of MiRNA Transcription Mononuclear Cell Differentiation DNA-templated Transcription Negative Regulation Of Metabolic Process Positive Regulation Of MiRNA Metabolic Process Nucleoplasm DNA-binding Transcription Factor Binding
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