BATF and COX8A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		BATF	COX8A
Description		basic leucine zipper ATF-like transcription factor	cytochrome c oxidase subunit 8A
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Mitochondrion Mitochondrial Inner Membrane Membrane Mitochondrial Membrane Respiratory Chain Complex IV
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Cytochrome-c Oxidase Activity Protein Binding
	Biological Process	Positive Regulation Of Cytokine Production Lymphoid Progenitor Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II DNA Damage Response Cell Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator Defense Response To Protozoan Myeloid Dendritic Cell Differentiation T-helper 2 Cell Differentiation Isotype Switching Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation T-helper 17 Cell Differentiation T-helper 17 Cell Lineage Commitment Integrated Stress Response Signaling Regulation Of T-helper 17 Cell Differentiation	Generation Of Precursor Metabolites And Energy Oxidative Phosphorylation Mitochondrial Electron Transport, Cytochrome C To Oxygen Cellular Respiration Proton Transmembrane Transport
Pathways		Interleukin-4 and Interleukin-13 signaling	TP53 Regulates Metabolic Genes Respiratory electron transport Cytoprotection by HMOX1 Complex IV assembly
Drugs			Cholic Acid N-Formylmethionine
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Multiple sclerosis ( 21833088 24076602 31604244)	Bipolar disorder ( 31043756)
Interacting Genes		21 interacting genes: ATF2 ATF3 ATF4 BATF3 CEBPA CEBPE CEBPG COX8A DBP DDIT3 EPAS1 FOS GOPC IFI35 IRF4 JUN JUNB JUND KDM1A NFIL3 SNAPC5	5 interacting genes: AMBP BATF EDDM3B MAGEA4 NPM1
Entrez ID		10538	1351
HPRD ID		09820	00468
Ensembl ID		ENSG00000156127	ENSG00000176340
Uniprot IDs		Q16520	P10176 Q53XN1
PDB IDs			5Z62 8D4T
Enriched GO Terms of Interacting Partners?		RNA Polymerase II Transcription Regulator Complex Integrated Stress Response Signaling DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II Sequence-specific Double-stranded DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Leukocyte Differentiation Myeloid Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Transcription Factor AP-1 Complex DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mononuclear Cell Differentiation Myeloid Leukocyte Differentiation Transcription Cis-regulatory Region Binding Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Intracellular Signaling Cassette Nucleobase-containing Compound Biosynthetic Process Cell Differentiation Transcription By RNA Polymerase II Sequence-specific DNA Binding Cellular Response To Metal Ion Cellular Developmental Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Response To Stress Liver Development CAMP Response Element Binding Protein Binding Macromolecule Biosynthetic Process Leucine Zipper Domain Binding Nucleoplasm Regulation Of Gene Expression	Myeloid Leukocyte Differentiation Myeloid Cell Differentiation T Cell Differentiation Involved In Immune Response Mononuclear Cell Differentiation Cytochrome C Metabolic Process T Cell Activation Involved In Immune Response Leukocyte Differentiation IgE Receptor Activity Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Collagen Fibril Binding Calcium Oxalate Binding Cytochrome Metabolic Process Protein Homodimerization Activity IgA Binding Leukocyte Activation Involved In Immune Response Positive Regulation Of Type I Hypersensitivity Mast Cell Apoptotic Process Serotonin Secretion Negative Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Type IIa Hypersensitivity Cell Activation Involved In Immune Response Serotonin Secretion By Platelet T Cell Differentiation Lymphocyte Activation Involved In Immune Response Fc-gamma Receptor III Complex Myeloid Leukocyte Activation Fc-epsilon Receptor I Complex Positive Regulation Of Type III Hypersensitivity Regulation Of Endoribonuclease Activity T-helper 17 Cell Differentiation Positive Regulation Of Mast Cell Cytokine Production IgE Binding Regulation Of Mast Cell Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Positive Regulation Of Centrosome Duplication Matrix Side Of Mitochondrial Inner Membrane Positive Regulation Of Hypersensitivity Interleukin-3-mediated Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Apoptotic Process Regulation Of Adaptive Immune Response Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Protein Localization To Nucleolus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Granular Component Negative Regulation Of Programmed Cell Death
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