SEMA3C and SGCE

		SEMA3C	SGCE
Description		semaphorin 3C	sarcoglycan epsilon
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Exosome	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Sarcoglycan Complex Membrane Dendrite Dendrite Membrane Sarcolemma Cell Projection
	Molecular Function	Protein Binding Semaphorin Receptor Binding Neuropilin Binding Chemorepellent Activity
	Biological Process	Neural Crest Cell Migration Somitogenesis Blood Vessel Remodeling Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Right Ventricle Morphogenesis Pulmonary Myocardium Development Immune Response Nervous System Development Axon Guidance Heart Development Response To Xenobiotic Stimulus Post-embryonic Development Neural Tube Development Cell Differentiation Positive Regulation Of Cell Migration Negative Chemotaxis Limb Bud Formation Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Semaphorin-plexin Signaling Pathway Cardiac Endothelial To Mesenchymal Transition Positive Regulation Of Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis	Cell-matrix Adhesion Muscle Organ Development
Pathways			Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases			Primary torsion dystonia (PTD)
GWAS		Bilirubin levels ( 19414484) Blood protein levels ( 30072576) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Diastolic blood pressure ( 27841878) Glaucoma ( 31959993 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) HDL cholesterol ( 27036123) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Intraocular pressure ( 29617998 29235454 30054594 31959993) Metabolite levels ( 23823483) Posterior cortical atrophy and Alzheimer's disease ( 26993346) Red blood cell count ( 32888494) Resistance to antihypertensive treatment in hypertension ( 31545351) Rosacea symptom severity ( 29771307) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: NRP1 NRP2	4 interacting genes: ARIH2 CWC15 KEAP1 PPP1CC
Entrez ID		10512	8910
HPRD ID		04034	04999
Ensembl ID		ENSG00000075223	ENSG00000127990
Uniprot IDs		Q99985	A0A0S2Z4P5 A0A2R8Y448 A0A2R8Y5J3 A0A2R8YGQ3 B4DP78 C9JR67 E9PEH6 O43556
PDB IDs
Enriched GO Terms of Interacting Partners?		Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Ventral Trunk Neural Crest Cell Migration Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Cranial Ganglion Development Trigeminal Nerve Structural Organization Neural Crest Cell Migration Involved In Autonomic Nervous System Development Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Trunk Neural Crest Cell Migration Sympathetic Neuron Projection Extension Vascular Endothelial Growth Factor Receptor Activity Branchiomotor Neuron Axon Guidance Hypothalamus Cell Migration Facial Nerve Structural Organization Sympathetic Ganglion Development Axon Extension Involved In Axon Guidance Semaphorin Receptor Activity Semaphorin Receptor Complex Ganglion Development Anatomical Structure Arrangement Vascular Endothelial Growth Factor Signaling Pathway Motor Neuron Axon Guidance Outflow Tract Septum Morphogenesis Cytokine Binding Semaphorin-plexin Signaling Pathway Growth Factor Binding Axon Extension Neural Crest Cell Migration Mesenchymal Cell Migration Cardiac Septum Morphogenesis Neuron Projection Extension Positive Regulation Of Endothelial Cell Proliferation Developmental Cell Growth Positive Regulation Of Endothelial Cell Migration Ameboidal-type Cell Migration Otic Placode Development Basal Dendrite Development Developmental Growth Involved In Morphogenesis Neuron Migration Regulation Of Endothelial Cell Proliferation Heparin Binding Renal Artery Morphogenesis VEGF-activated Neuropilin Signaling Pathway Trigeminal Nerve Morphogenesis Endothelial Tip Cell Fate Specification Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Proliferation
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