ZNF267 and BCKDK

		ZNF267	BCKDK
Description		zinc finger protein 267	branched chain keto acid dehydrogenase kinase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Mitochondrion Mitochondrial Matrix Oxoglutarate Dehydrogenase Complex
	Molecular Function	DNA Binding Zinc Ion Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine Phosphatase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity Protein Serine Kinase Activity Catalytic Activity, Acting On A Protein
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	L-isoleucine Catabolic Process L-leucine Catabolic Process L-valine Catabolic Process Spermatogenesis Lipid Biosynthetic Process Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Regulation Of Pyruvate Decarboxylation To Acetyl-CoA Regulation Of Glucose Metabolic Process
Pathways		Generic Transcription Pathway	Branched-chain amino acid catabolism Branched-chain ketoacid dehydrogenase kinase deficiency
Drugs			Adenosine 5'-[gamma-thio]triphosphate
Diseases
GWAS			Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Parkinson's disease ( 25064009) Systolic blood pressure ( 31928498) Triglyceride levels ( 31928498) Waist circumference ( 31928498)
Interacting Genes		4 interacting genes: ADORA2B ATP6V0A1 EPHA7 TRIM54	11 interacting genes: APP EPS8 FBXO7 FXR1 FXR2 LSM8 NR5A2 SPTA1 STAT3 TRAF4 UBC
Entrez ID		10308	10295
HPRD ID		06883	12523
Ensembl ID		ENSG00000185947	ENSG00000103507
Uniprot IDs		Q14586	O14874
PDB IDs			8F5F 8F5J 8F5S 9DI9
Enriched GO Terms of Interacting Partners?			Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Neuronal Synaptic Plasticity Neuron Projection Positive Regulation Of Catabolic Process Regulation Of Developmental Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Purine Nucleotide Metabolic Process Regulation Of Stem Cell Differentiation Translation Regulator Activity Positive Regulation Of JNK Cascade Regulation Of Cell Differentiation Positive Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Positive Regulation Of MRNA Catabolic Process Regulation Of Biological Quality Stem Cell Population Maintenance Maintenance Of Cell Number Ubiquitin Protein Ligase Binding Regulation Of MiRNA-mediated Gene Silencing Dentate Gyrus Development Positive Regulation Of Phosphate Metabolic Process Regulation Of Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Cell Shape Regulation Of JNK Cascade Post-transcriptional Regulation Of Gene Expression Protein Heterodimerization Activity Actin Filament Capping Positive Regulation Of MRNA Metabolic Process Cytoplasmic Translational Initiation Amyloid-beta Complex Axon Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Regulation Of Tumor Necrosis Factor Production Amylin Binding Positive Regulation Of ATP Metabolic Process Positive Regulation Of Toll Signaling Pathway Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Actin Filament Depolymerization Temperature Homeostasis Regulation Of Stress-activated Protein Kinase Signaling Cascade Regulation Of Stress-activated MAPK Cascade Zygotic Genome Activation Positive Regulation Of Guanylate Cyclase Activity Presynaptic Modulation Of Chemical Synaptic Transmission
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