SIGMAR1 and DCAF12

		SIGMAR1	DCAF12
Description		sigma non-opioid intracellular receptor 1	DDB1 and CUL4 associated factor 12
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Cytosol Plasma Membrane Postsynaptic Density Membrane Growth Cone Cytoplasmic Vesicle Cell Projection Synapse Postsynaptic Membrane Anchoring Junction Postsynapse Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	G Protein-coupled Opioid Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Lipid Transport Nervous System Development G Protein-coupled Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Protein Homotrimerization Regulation Of Postsynapse Assembly	Spermatogenesis Regulation Of Autophagy Protein Ubiquitination MiRNA-mediated Gene Silencing By MRNA Destabilization T Cell Activation Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway
Pathways		Potential therapeutics for SARS
Drugs		Amitriptyline Remoxipride Haloperidol Dextromethorphan Nortriptyline Fenfluramine Pentazocine Naltrexone Cocaine Hydrocodone Sertraline Dimethyltryptamine Prasterone Phencyclidine Pimavanserin Noscapine Captodiame Pentoxyverine
Diseases
GWAS			Alanine aminotransferase levels ( 33547301) BRCA1/2-negative high-risk breast cancer ( 30323354) Daytime nap ( 33568662) Estimated glomerular filtration rate ( 30604766 31015462) Granulocyte percentage of myeloid white cells ( 27863252) Liver enzyme levels (alanine transaminase) ( 33972514) Mean corpuscular hemoglobin ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Platelet distribution width ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		5 interacting genes: ANK2 GHSR ITPR3 PDZD11 SRI	4 interacting genes: BMPR1B CCT5 CUL4B TGFBR1
Entrez ID		10280	25853
HPRD ID		03580	10031
Ensembl ID		ENSG00000147955	ENSG00000198876
Uniprot IDs		A0A7P0T9D5 A0A7P0Z4C2 B4DR71 Q99720	Q5T6F0
PDB IDs		5HK1 5HK2 6DJZ 6DK0 6DK1	3I7P 8AJM 8AJN 8AJO 8T9A
Enriched GO Terms of Interacting Partners?			Transforming Growth Factor Beta Receptor Activity, Type I Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Chondrocyte Differentiation SMAD Binding Regulation Of Cartilage Development Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway HFE-transferrin Receptor Complex Regulation Of Extrinsic Apoptotic Signaling Pathway Receptor Complex Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Chondrocyte Proliferation BMP Receptor Activity Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Ovarian Cumulus Expansion Endochondral Bone Morphogenesis Regionalization Positive Regulation Of Mesenchymal Stem Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Myofibroblast Differentiation Activin Receptor Complex Activin Receptor Activity, Type I Type II Transforming Growth Factor Beta Receptor Binding Ventricular Compact Myocardium Morphogenesis Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Coronary Artery Morphogenesis Parathyroid Gland Development Positive Regulation Of Tight Junction Disassembly Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Germ Cell Migration Positive Regulation Of Extracellular Matrix Assembly Vascular Endothelial Cell Proliferation Transforming Growth Factor Beta Receptor Activity Epicardium Morphogenesis Trophoblast Cell Migration Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Endothelial Cell Activation Transforming Growth Factor Beta Ligand-receptor Complex Cul4B-RING E3 Ubiquitin Ligase Complex G Protein-coupled Opioid Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Positive Regulation Of Telomerase RNA Localization To Cajal Body Positive Regulation Of Protein Localization To Cajal Body Chaperonin-containing T-complex Ubiquitin Protein Ligase Binding Coronary Vasculature Morphogenesis Activin Binding UV-damage Excision Repair Response To Growth Factor
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