MPHOSPH10 and NEUROG1

		MPHOSPH10	NEUROG1
Description		M-phase phosphoprotein 10	neurogenin 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Sno(s)RNA-containing Ribonucleoprotein Complex Small-subunit Processome Mpp10 Complex Ribonucleoprotein Complex	Chromatin Nucleus Neuronal Cell Body Perikaryon
	Molecular Function	RNA Binding Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions RRNA Processing RNA Processing RNA Splicing Maturation Of SSU-rRNA Ribosome Biogenesis Ribosomal Small Subunit Biogenesis	Regulation Of Transcription By RNA Polymerase II Thorax And Anterior Abdomen Determination Nervous System Development Sensory Organ Development Exit From Mitosis Trigeminal Nerve Development Vestibulocochlear Nerve Formation Neurogenesis Cell Differentiation Neuron Differentiation Peristalsis Forebrain Development Auditory Behavior Positive Regulation Of Exit From Mitosis Genitalia Morphogenesis Inner Ear Morphogenesis Cell Fate Commitment Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Organ Development Genitalia Development Inner Ear Development Neuromuscular Process Controlling Balance Positive Regulation Of DNA-binding Transcription Factor Activity Axon Development Mastication Cochlea Development Cochlea Morphogenesis Craniofacial Suture Morphogenesis Learned Vocalization Behavior Negative Regulation Of Relaxation Of Muscle Negative Regulation Of Saliva Secretion Hard Palate Morphogenesis
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Metabolite levels ( 23823483)
Interacting Genes		5 interacting genes: CSNK2A1 IMP3 IMP4 PPP1CA RNF10	7 interacting genes: CBFA2T2 CREBBP RUNX1T1 SMAD1 TARBP2 TCF12 TCF4
Entrez ID		10199	4762
HPRD ID		10404	03430
Ensembl ID		ENSG00000124383	ENSG00000181965
Uniprot IDs		O00566	F1T0H3 Q92886
PDB IDs		7MQ8 7MQ9 7MQA
Enriched GO Terms of Interacting Partners?		Preribosome Mpp10 Complex Regulation Of Apoptotic Signaling Pathway SnoRNA Binding Protein Serine/threonine Kinase Inhibitor Activity Negative Regulation Of Apoptotic Signaling Pathway Double-strand Break Repair Via Nonhomologous End Joining Hsp90 Protein Binding Regulation Of Glial Cell Proliferation Dinitrosyl-iron Complex Binding S-nitrosoglutathione Binding Nitric Oxide Storage Prenylcysteine Oxidase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Oxygen As Acceptor Prenylcysteine Catabolic Process Farnesylcysteine Lyase Activity RRNA Binding Maturation Of SSU-rRNA Regulation Of Translational Initiation Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Protein Kinase CK2 Complex RNA Metabolic Process Symbiont-mediated Disruption Of Host Cell PML Body Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Forebrain Development Regulation Of Gliogenesis Regulation Of Fibroblast Proliferation Lens Fiber Cell Apoptotic Process TRAF2-GSTP1 Complex Glutathione Derivative Biosynthetic Process Cellular Response To Cell-matrix Adhesion Learned Vocalization Behavior Hard Palate Morphogenesis Mastication Vestibulocochlear Nerve Formation Positive Regulation Of Exit From Mitosis Negative Regulation Of Saliva Secretion Iron Ion Binding Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Positive Regulation Of Termination Of DNA-templated Transcription Positive Regulation Of Termination Of RNA Polymerase II Transcription RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Positive Regulation Of Termination Of RNA Polymerase II Transcription, Poly(A)-coupled Prenylated Protein Catabolic Process Small-subunit Processome Ribosomal Small Subunit Biogenesis	Transcription Regulator Complex Transcription Corepressor Activity DNA-binding Transcription Factor Binding MiRNA Processing Nucleoplasm Regulation Of Cell Differentiation E-box Binding DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Nucleic Acid Metabolic Process Nucleus Histone H3K27 Acetyltransferase Activity Chromatin Homomeric SMAD Protein Complex DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Differentiation Regulation Of SiRNA Processing Positive Regulation Of Neuron Differentiation Regulation Of RNA Metabolic Process Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Global Gene Silencing By MRNA Cleavage Beta-catenin-TCF7L2 Complex Mpp10 Complex Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Developmental Process Negative Regulation Of Defense Response To Virus By Host TFIIB-class Transcription Factor Binding RNA Metabolic Process Regulation Of Developmental Process MRF Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Positive Regulation Of Neuron Projection Development Anti-Mullerian Hormone Receptor Signaling Pathway Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Activity Protein Dimerization Activity
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