PLXNC1 and CKAP4

		PLXNC1	CKAP4
Description		plexin C1	cytoskeleton associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse	Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Lipid Droplet Cytoskeleton Plasma Membrane Membrane Nuclear Speck Azurophil Granule Membrane Specific Granule Membrane Lamellar Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Semaphorin Receptor Activity	RNA Binding Protein Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Synapse Assembly Regulation Of Cell Shape Regulation Of Cell Migration Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Regulation Of Synapse Pruning
Pathways		Other semaphorin interactions	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Neutrophil degranulation Post-translational protein phosphorylation RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31959851 32296059 34103634) Blood protein levels ( 30072576) Diastolic blood pressure ( 30578418) Femur bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602) Multiple sclerosis ( 31604244) Pulse pressure ( 30578418) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: SEMA7A	15 interacting genes: ASCC2 ATF4 DKK1 HAMP LINC01554 MLH1 MVP NDUFB7 NEIL3 NKX3-1 OGT PLAT THOC7 TSNAX WASHC3
Entrez ID		10154	10970
HPRD ID		05036	16717
Ensembl ID		ENSG00000136040	ENSG00000136026
Uniprot IDs		O60486	Q07065
PDB IDs		3KUZ 3NVN 3NVQ 6VXK
Enriched GO Terms of Interacting Partners?		Olfactory Lobe Development
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