ACTR1A and CNNM2

		ACTR1A	CNNM2
Description		actin related protein 1A	cyclin and CBS domain divalent metal cation transport mediator 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centrosome Microtubule Organizing Center Cytosol Cytoskeleton Dynactin Complex Microtubule Associated Complex Cell Cortex Extracellular Exosome	Plasma Membrane Membrane Basolateral Plasma Membrane Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding	ATP Binding Magnesium Ion Transmembrane Transporter Activity
	Biological Process	Vesicle-mediated Transport	Monoatomic Ion Transport Magnesium Ion Homeostasis Magnesium Ion Transport Magnesium Ion Transmembrane Transport
Pathways		MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Prostate cancer ( 23535732) Refractive error ( 32231278) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Anxiety/tension (special factor of neuroticism) ( 30867560) Arsenic metabolism ( 22383894) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21572416) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 33020668 29212778 26343387 24262325) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Creatine kinase levels ( 29403010) Diastolic blood pressure ( 30487518) Estimated glomerular filtration rate ( 31015462) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 32709000 30487518 31879980) Intracranial aneurysm ( 20364137) Mean arterial pressure ( 30487518 27618448) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 27863252 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Microalbuminuria ( 26631737) Myocardial infarction ( 26343387) Number of sexual partners ( 30643258) Parkinson's disease ( 19915575) Prostate cancer ( 23535732) Pulse pressure ( 30487518) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 21926974 22688191 23894747 23974872 25056061 28991256 29483656 30285260) Smoking initiation ( 30617275 33082346) Systolic blood pressure ( 19430483 30487518 30578418) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) White blood cell count ( 32888494) White matter lesion progression ( 26451028)
Interacting Genes		7 interacting genes: CEBPA DCTN1 DCTN4 NUMA1 SNCA SPTBN1 SPTBN2
Entrez ID		10121	54805
HPRD ID		05507	07418
Ensembl ID		ENSG00000138107	ENSG00000148842
Uniprot IDs		A0A384NQ21 B4DXP9 P61163	Q9H8M5
PDB IDs			4IY0 4IY2 4IY4 4IYS 6DJ3 6N7E 8F6D
Enriched GO Terms of Interacting Partners?		Cell Cortex Cell Cortex Region Regulation Of Supramolecular Fiber Organization Regulation Of Protein-containing Complex Assembly Regulation Of Cytoskeleton Organization Regulation Of Microtubule Polymerization Positive Regulation Of Protein Localization To Cell Periphery Spectrin Regulation Of Microtubule Polymerization Or Depolymerization Protein-containing Complex Neuronal Cell Body Cytoskeleton Phospholipid Binding Negative Regulation Of Protein-containing Complex Assembly Spindle Pole Regulation Of Protein Localization To Cell Periphery Dynein Complex Binding Negative Regulation Of Supramolecular Fiber Organization Negative Regulation Of Cytoskeleton Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule Plus-end Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Actin Filament Capping Regulation Of Organelle Organization Establishment Of Mitotic Spindle Orientation Protein Domain Specific Binding Negative Regulation Of Actin Filament Depolymerization Establishment Of Mitotic Spindle Localization Regulation Of Mitotic Spindle Organization Establishment Of Spindle Orientation Tau Protein Binding Microtubule Binding Synapse Organization Regulation Of Microtubule-based Process Negative Regulation Of Actin Filament Polymerization Establishment Of Organelle Localization Regulation Of Actin Filament Depolymerization RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Macrophage Activation Establishment Of Spindle Localization Tubulin Binding Spindle Localization Cortical Microtubule Anastral Spindle Assembly Cytoplasmic Microtubule Bundle Positive Regulation Of Protein Localization To Spindle Pole Body Positive Regulation Of Mitotic Spindle Elongation Response To Desipramine Negative Regulation Of Norepinephrine Uptake	Arsenite Methyltransferase Activity Arsonoacetate Metabolic Process
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