ABCB6 and PIK3R3

Number of citations of the paper that reports this interaction (PMID 18624398)
4

Data Source:
BioGRID (two hybrid)

		ABCB6	PIK3R3
Gene Name		ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)	phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Mitochondrial Outer Membrane ATP-binding Cassette (ABC) Transporter Complex Extracellular Vesicular Exosome	Cytosol Phosphatidylinositol 3-kinase Complex
	Molecular Function	ATP Binding Heme Transporter Activity Heme-transporting ATPase Activity Efflux Transmembrane Transporter Activity Heme Binding	Protein Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Regulator Activity
	Biological Process	Porphyrin-containing Compound Biosynthetic Process Transport Cellular Iron Ion Homeostasis Brain Development Heme Transport Skin Development Transmembrane Transport	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Activity Small Molecule Metabolic Process
Pathways		Mitochondrial ABC transporters ABC-family proteins mediated transport	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Gastrin-CREB signalling pathway via PKC and MAPK Interleukin-7 signaling Phospholipid metabolism Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR Signaling by Interleukins GPCR downstream signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System G alpha (q) signalling events Costimulation by the CD28 family PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR G alpha (12/13) signalling events PI Metabolism Innate Immune System Signalling by NGF Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR GPVI-mediated activation cascade Interleukin receptor SHC signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: PIK3R3	38 interactors: ABCB6 AMBP AXL DARS DRAP1 DSN1 EGFR ERBB2 ERBB3 ESR1 FBN3 FGB FSD2 GC IGF1R INSR IRS1 IRS2 KARS KHDRBS1 KIAA1377 KLC2 L3MBTL3 LUC7L2 MBIP MICAL1 ORM1 PDGFRB PIK3CA PSME1 QARS RB1 RING1 SERF1A TEC TRIM54 TRMT2A VBP1
Entrez ID		10058	8503
HPRD ID		09261	05831
Ensembl ID		ENSG00000115657	ENSG00000117461
Uniprot IDs		Q9NP58	F6TDL0 Q8N381 Q92569
PDB IDs		3NH6 3NH9 3NHA 3NHB
Enriched GO Terms of Interacting Partners?		Phosphatidylinositol-3-phosphate Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Activity Regulation Of Lipid Kinase Activity Phosphatidylinositol Phosphorylation Lipid Phosphorylation Phosphatidylinositol Biosynthetic Process Insulin Receptor Signaling Pathway Glycerophospholipid Biosynthetic Process Lipid Modification Cellular Response To Insulin Stimulus Phosphatidylinositol Metabolic Process Phospholipid Biosynthetic Process Response To Insulin Regulation Of Lipid Metabolic Process Glycerophospholipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide	Phosphatidylinositol-mediated Signaling Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Fc-epsilon Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Innate Immune Response Immune System Process Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol 3-kinase Signaling Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Negative Regulation Of Cell Death Cellular Response To Hormone Stimulus Positive Regulation Of Signal Transduction Wound Healing Positive Regulation Of Cell Cycle Regulation Of Protein Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of MAPK Cascade Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Defense Response Organ Development Negative Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Regulation Of Signaling Response To Wounding Protein Autophosphorylation Regulation Of Apoptotic Process Regulation Of Signal Transduction Negative Regulation Of Signaling Peptidyl-amino Acid Modification
Tagcloud ?		ahr antioxidants arsenic biomarker chaperones characterize contaminant detailed detoxificants differentially exposure exposures hmox1 hrs ias inorganic keap1 nrf2 represented responsive risen route sqstm1 sublethal suitable transcript transcriptionally unrecognized worldwide	akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
Tagcloud (Difference) ?		ahr antioxidants arsenic biomarker chaperones characterize contaminant detailed detoxificants differentially exposure exposures hmox1 hrs ias inorganic keap1 nrf2 represented responsive risen route sqstm1 sublethal suitable transcript transcriptionally unrecognized worldwide	akt carcinogenesis diagnostic downregulated elucidating hcc hepatocellular insights invasion inversely investigations lead malignancy markedly micrornas migration mir mirnas mtor negatively phosphoinositide regulating repressing strategies suppressed suppression taken tissues underlying
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