ABCB6

Description		ATP binding cassette subfamily B member 6 (LAN blood group)
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleoplasm Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Lysosome Lysosomal Membrane Endosome Vacuolar Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Late Endosome Membrane Multivesicular Body Membrane Melanosome Membrane Endolysosome Membrane ATP-binding Cassette (ABC) Transporter Complex Extracellular Exosome
	Molecular Function	Nucleotide Binding ATP Binding Heme Transmembrane Transporter Activity ABC-type Heme Transporter Activity Efflux Transmembrane Transporter Activity ATP Hydrolysis Activity Heme Binding Tetrapyrrole Binding ABC-type Transporter Activity
	Biological Process	Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Heme B Biosynthetic Process Intracellular Copper Ion Homeostasis Intracellular Iron Ion Homeostasis Brain Development Heme Transport Tetrapyrrole Metabolic Process Iron Ion Transmembrane Transport Heme Transmembrane Transport Heme Metabolic Process Skin Development Transmembrane Transport Cellular Detoxification Of Cadmium Ion Melanosome Assembly
Pathways		Mitochondrial ABC transporters Defective ABCB6 causes MCOPCB7
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		1 interacting genes: PIK3R3
Entrez ID		10058
HPRD ID		09261
Ensembl ID		ENSG00000115657
Uniprot IDs		Q9NP58
PDB IDs		3NH6 3NH9 3NHA 3NHB 7D7N 7D7R 7DNY 7DNZ 7EKL 7EKM 8FWK 8K7B 8K7C 8YR3 8YR4 9DBQ
Enriched GO Terms of Interacting Partners?		1-phosphatidylinositol-3-kinase Activity 1-phosphatidylinositol-3-kinase Regulator Activity Phosphatidylinositol 3-kinase Complex Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol-3-phosphate Biosynthetic Process Cell Migration Involved In Sprouting Angiogenesis Regulation Of Anoikis Negative Regulation Of Anoikis Blood Vessel Endothelial Cell Migration Phosphotyrosine Residue Binding Phosphatidylinositol Phosphate Biosynthetic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Endothelial Cell Migration Insulin Receptor Signaling Pathway Phosphatidylinositol Biosynthetic Process B Cell Differentiation Phosphatidylinositol Metabolic Process T Cell Differentiation Glycerophospholipid Biosynthetic Process B Cell Activation Phospholipid Biosynthetic Process
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