SDIM1 and DNAJB4

Number of citations of the paper that reports this interaction (PubMedID 21255413)
26

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SDIM1	DNAJB4
Description		stress responsive DNAJB4 interacting membrane protein 1	DnaJ heat shock protein family (Hsp40) member B4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Z Disc
	Molecular Function	Protein Binding Protein Homodimerization Activity	ATPase Activator Activity Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding
	Biological Process	Protein Folding	Negative Regulation Of Transcription By RNA Polymerase II Protein Folding Response To Unfolded Protein Response To Heat
Pathways
Drugs
Diseases
GWAS			Adult body size ( 32376654) Appendicular lean mass ( 33097823) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous melanoma or hair colour ( 32341527) Diastolic blood pressure ( 30224653) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Waist circumference ( 25673412)
Interacting Genes		1 interacting genes: DNAJB4	11 interacting genes: HSPA1A HSPA6 MDM2 OPRM1 PABPN1 POLR1D RUVBL2 SDIM1 SMAD3 TBL1X TBPL2
Entrez ID		100505705	11080
HPRD ID			07486
Ensembl ID			ENSG00000162616
Uniprot IDs			B4DNN2 Q9UDY4
PDB IDs
Enriched GO Terms of Interacting Partners?			Regulation Of Protein Stability Protein Folding Cellular Heat Acclimation Protein Stabilization Unfolded Protein Binding Negative Regulation Of Cytosolic Calcium Ion Concentration Enzyme Binding Disordered Domain Specific Binding Protein Refolding Transcription Corepressor Activity ATP-dependent Protein Folding Chaperone COP9 Signalosome Regulation Of Cellular Response To Stress Cellular Response To Alkaloid Cellular Response To Heat Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Protein Folding Chaperone Heat Shock Protein Binding Regulation Of Canonical Wnt Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Lung Blood Pressure Positive Regulation Of Nucleocytoplasmic Transport Nuclear Mineralocorticoid Receptor Binding Regulation Of Nitric Oxide Metabolic Process Transcription Repressor Complex Response To Formaldehyde Cellular Response To Vitamin B1 Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Positive Regulation Of Polynucleotide Adenylyltransferase Activity Ubiquitin Protein Ligase Binding Regulation Of Wnt Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process ATP Hydrolysis Activity Denatured Protein Binding Negative Regulation Of RNA Metabolic Process Response To Unfolded Protein Response To Heat Regulation Of Protein Catabolic Process Negative Regulation Of Biosynthetic Process Response To Lipid Positive Regulation Of Transforming Growth Factor Beta3 Production Chromatin DNA Binding Positive Regulation Of Intracellular Protein Transport Response To Alkaloid Cellular Response To UV Nuclear DNA-directed RNA Polymerase Complex Ribonucleoprotein Complex
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