PIGK and ALPP

Number of citations of the paper that reports this interaction (PubMedID 12616539)
0

Data Source:
HPRD (in vitro, in vivo)

		PIGK	ALPP
Description		phosphatidylinositol glycan anchor biosynthesis class K	alkaline phosphatase, placental
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GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane GPI-anchor Transamidase Complex	Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	GPI-anchor Transamidase Activity Protein Binding Peptidase Activity Transferase Activity GPI Anchor Binding	Magnesium Ion Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	GPI Anchor Biosynthetic Process Proteolysis Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis
Pathways		Attachment of GPI anchor to uPAR	Intra-Golgi traffic
Drugs			Calcium METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
Diseases
GWAS		Chronotype ( 27494321 30696823) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Type 2 diabetes (age of onset) ( 28060188)	Blood protein levels ( 30072576) Height ( 19570815) Refractive error ( 32231278)
Interacting Genes		3 interacting genes: ALPP GPAA1 PIGT	47 interacting genes: ADAMTSL4 ALPG CRCT1 CREB5 CXCL5 CYSRT1 FBXO34 GEMIN4 GPLD1 GSC2 HOXA1 IGFBP6 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP5-9 KRTAP9-3 LATS1 LCE1B LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 NBPF19 NLGN3 NOTCH2NLA NR4A3 NUFIP2 OTX1 PIGK POU4F2 RGS19 RGS20 SMCP TGM1
Entrez ID		10026	250
HPRD ID		05474	01379
Ensembl ID		ENSG00000142892	ENSG00000163283
Uniprot IDs		Q92643	B2R7C7 P05187
PDB IDs		7W72 7WLD 8IMX 8IMY	1EW2 1ZEB 1ZED 1ZEF 2GLQ 3MK0 3MK1 3MK2
Enriched GO Terms of Interacting Partners?		GPI-anchor Transamidase Complex Attachment Of GPI Anchor To Protein GPI Anchored Protein Biosynthesis GPI Anchor Binding GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Glycolipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphatidylinositol Metabolic Process Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process GPI-anchor Transamidase Activity Glycerophospholipid Metabolic Process Alkaline Phosphatase Activity Protein Maturation Glycerolipid Metabolic Process Phospholipid Metabolic Process Protein Retention In ER Lumen Maintenance Of Protein Localization In Endoplasmic Reticulum Carbohydrate Derivative Biosynthetic Process Lipid Biosynthetic Process Organophosphate Biosynthetic Process Carbohydrate Derivative Metabolic Process Maintenance Of Protein Localization In Organelle Organophosphate Metabolic Process Maintenance Of Protein Location In Cell Maintenance Of Protein Location Endoplasmic Reticulum Membrane Lipid Metabolic Process Maintenance Of Location In Cell Phosphatase Activity Maintenance Of Location Phosphate-containing Compound Metabolic Process Neuron Apoptotic Process Side Of Membrane Endoplasmic Reticulum	Keratinization Epidermis Development Tissue Development Intermediate Filament Keratin Filament Identical Protein Binding
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