CDH3 and CDH5

		CDH3	CDH5
Description		cadherin 3	cadherin 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Adherens Junction Membrane Catenin Complex Cell Junction	Nucleoplasm Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction External Side Of Plasma Membrane Cell Surface Membrane Catenin Complex Cell Junction Nuclear Membrane Anchoring Junction Cell Periphery
	Molecular Function	Calcium Ion Binding Beta-catenin Binding Cadherin Binding Metal Ion Binding	Signaling Receptor Binding Calcium Ion Binding Protein Binding Beta-catenin Binding Protein Phosphatase Binding Signaling Receptor Complex Adaptor Activity Vascular Endothelial Growth Factor Receptor 2 Binding Transmembrane Transporter Binding Cadherin Binding Metal Ion Binding Fibrinogen Binding BMP Receptor Binding Cell-cell Adhesion Mediator Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Morphogenesis Retina Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Visual Perception Positive Regulation Of Gene Expression Positive Regulation Of Keratinocyte Proliferation Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Hair Cycle Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Keratinization Positive Regulation Of Tyrosinase Activity Adherens Junction Organization Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Melanin Biosynthetic Process Regulation Of Transport Negative Regulation Of Timing Of Catagen Positive Regulation Of Canonical Wnt Signaling Pathway Cell-cell Adhesion Positive Regulation Of Melanosome Transport	Cell Morphogenesis Endothelial Cell Morphogenesis Blood Vessel Maturation Cell Migration Involved In Sprouting Angiogenesis Intracellular Calcium Ion Homeostasis Cell-cell Junction Assembly Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell Surface Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of BMP Signaling Pathway Negative Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Adherens Junction Organization Maintenance Of Blood-brain Barrier Regulation Of Vascular Permeability Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Bicellular Tight Junction Assembly Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Adherens junctions interactions	Adherens junctions interactions VEGFR2 mediated vascular permeability High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs			Lenalidomide FX06
Diseases		Hypotrichosis, congenital, with juvenile macular dystrophy Ectodermal dysplasia, ectrodactyly, and macular dystrophy (EEM syndrome)
GWAS		Cutaneous melanoma or hair colour ( 32341527) Glycated hemoglobin levels ( 28898252) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 24076602 31604244) Platelet count ( 32888494) Red cell distribution width ( 27863252) Ulcerative colitis ( 28067908)	Body size at age 10 ( 32376654) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) High light scatter reticulocyte count ( 32888494) Iron status biomarkers (ferritin levels) ( 28334935) Lung function (FEV1/FVC) ( 30061609) Molar-incisor hypomineralization ( 23918034) Reticulocyte count ( 32888494)
Interacting Genes		3 interacting genes: CTNNA1 CTNNB1 CTNND1	21 interacting genes: CSK CTNNA1 CTNNB1 CTNND1 DSP EGFR EPHA2 F2RL2 FGA JUP KDR P2RX4 P2RX6 PARD6A PKP4 PTPN11 PTPRB SHC1 SMG1 SRC VIM
Entrez ID		1001	1003
HPRD ID		00227	03075
Ensembl ID		ENSG00000062038	ENSG00000179776
Uniprot IDs		B4DLF0 P22223	P33151 Q59EA3
PDB IDs		4OY9 4ZML 4ZMN 4ZMO 4ZMP 4ZMQ 4ZMT 4ZMV 4ZMW 4ZMX 4ZMY 4ZMZ 5JYL 5JYM 6ZTB 6ZTR 7CME 7CMF 8HYI
Enriched GO Terms of Interacting Partners?		Catenin Complex Adherens Junction Cell-cell Junction Cell-cell Adhesion Mediated By Cadherin Cadherin Binding Anchoring Junction Cellular Response To Indole-3-methanol Response To Indole-3-methanol Cell-cell Adhesion Regulation Of Blood Vessel Branching Cell-cell Junction Assembly Flotillin Complex Cell-cell Junction Organization Cell Adhesion Cell Junction Cell Migration Cell Migration Involved In Sprouting Angiogenesis Cell Junction Assembly Cell Motility Regulation Of Angiogenesis Blood Vessel Endothelial Cell Migration Cell-cell Adhesion Mediator Activity Regulation Of Vasculature Development Regulation Of Endothelial Cell Differentiation Regulation Of Neuroblast Proliferation Neuroblast Proliferation Intercalated Disc Regulation Of Multicellular Organismal Development Signaling Receptor Binding Adherens Junction Organization Phosphatase Binding Regulation Of Morphogenesis Of A Branching Structure Cell Junction Organization Odontogenesis Of Dentin-containing Tooth Regulation Of Morphogenesis Of An Epithelium Endothelial Cell Migration Cell Periphery Protein Phosphatase Binding Cell Surface Receptor Signaling Pathway Regulation Of Neural Precursor Cell Proliferation Neural Precursor Cell Proliferation Odontogenesis Beta-catenin Binding Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Negative Regulation Of Blood Vessel Branching Negative Regulation Of Cell Population Proliferation Bicellular Tight Junction Transmembrane Transporter Binding Regulation Of Cell Development	Cadherin Binding Cell Adhesion Anchoring Junction Cell Junction Catenin Complex Cell-cell Junction Organization Cell-cell Adhesion Cellular Response To Indole-3-methanol Response To Indole-3-methanol Regulation Of Protein Localization Adherens Junction Cell-cell Junction Plasma Membrane Cell Junction Organization Cell Migration Negative Regulation Of Multicellular Organismal Process Regulation Of ERK1 And ERK2 Cascade Focal Adhesion Positive Regulation Of Protein Localization Adherens Junction Organization Cell Motility Cell-cell Junction Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cellular Localization Desmosome ERBB Signaling Pathway Cell Junction Assembly Regulation Of Cell Adhesion Regulation Of Transport Flotillin Complex Cell Adhesion Molecule Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of ERK1 And ERK2 Cascade Cell-cell Adhesion Mediated By Cadherin Response To Growth Factor Regulation Of MAPK Cascade Intercalated Disc Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Developmental Process Desmosome Organization Protein Tyrosine Kinase Activity Regulation Of Multicellular Organismal Process Shc-EGFR Complex Epithelial Cell-cell Adhesion Cell Surface Receptor Signaling Pathway Regulation Of Protein Transport Cellular Response To Growth Factor Stimulus Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
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