AKT3 and CCNT2

		AKT3	CCNT2
Description		AKT serine/threonine kinase 3	cyclin T2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Ciliary Basal Body	Nucleus Nucleoplasm Cytoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Transcription Coactivator Binding Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity RNA Polymerase Binding 7SK SnRNA Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Brain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Negative Regulation Of Cellular Senescence	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Skeletal Muscle Tissue Development Early Viral Transcription Late Viral Transcription Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Elongation By RNA Polymerase II Host-mediated Activation Of Viral Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Muscle Cell Differentiation Cell Division
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adult diffuse glioma (IDH mutation) ( 32386320) Adventurousness ( 30643258) Antisaccade task score ( 31596458) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) ghrelin levels ( 33852427) Height ( 28552196) Menarche (age at onset) ( 23599027) Monocyte count ( 32888494) Non-glioblastoma glioma ( 28346443) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 25056061 23974872 28991256 30285260 29483656) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Body mass index ( 26426971) Diisocyanate-induced asthma ( 25918132) Parkinson's disease ( 28892059) Waist-to-hip ratio adjusted for BMI ( 28552196) Walking pace ( 33128006)
Interacting Genes		12 interacting genes: CRYAA FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2	6 interacting genes: BRD4 CDK9 HEXIM1 PKN1 RB1 SUPT5H
Entrez ID		10000	905
HPRD ID		06441	04839
Ensembl ID		ENSG00000117020	ENSG00000082258
Uniprot IDs		A0A5F9ZHU3 A0A7P0TB32 A0A7P0TBJ6 Q9Y243	B4DH21 O60583
PDB IDs		2X18 8ZXW	2IVX
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase Binding Regulation Of Intracellular Transport Protein Modification Process Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cytoplasm Regulation Of Protein Stability Sodium Channel Inhibitor Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Membrane Potential Regulation Of Neuron Projection Development Potassium Channel Inhibitor Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Nucleus Regulation Of Potassium Ion Export Across Plasma Membrane Cytosol Protein Metabolic Process Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Establishment Of Cell Polarity Regulation Of Monoatomic Cation Transmembrane Transport Vascular Endothelial Cell Response To Fluid Shear Stress	Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of DNA-templated Transcription Elongation Negative Regulation Of DNA-templated Transcription, Elongation P-TEFb Complex Binding Positive Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of DNA-templated Transcription, Elongation Cyclin/CDK Positive Transcription Elongation Factor Complex 7SK SnRNA Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Protein Serine/threonine Kinase Activity SnRNA Binding Chromatin Binding Nucleoplasm Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Viral Transcription Chromatin Remodeling Transcription Elongation By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process DNA-templated Transcription Elongation Positive Regulation Of RNA Metabolic Process Protein Phosphorylation Protein Serine Kinase Activity Phosphorylation Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Host-mediated Perturbation Of Viral Process Enzyme Binding Histone H4K8ac Reader Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity P-TEFb Complex Positive Regulation Of Transcription By RNA Polymerase II Host-mediated Perturbation Of Symbiont Process Multicellular Organismal-level Homeostasis Positive Regulation Of Mitotic Cell Cycle Phase Transition DSIF Complex Histone H3K9ac Reader Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity PML Body Regulation Of Cellular Response To Stress Negative Regulation Of DNA-templated Transcription Nucleus Negative Regulation Of RNA Biosynthetic Process
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