SLC6A3 and MRPL36

		SLC6A3	MRPL36
Description		solute carrier family 6 member 3	mitochondrial ribosomal protein L36
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Membrane Flotillin Complex Axon Presynaptic Membrane Cell Projection Neuron Projection Neuronal Cell Body Axon Terminus Membrane Raft Postsynaptic Membrane Dopaminergic Synapse	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Large Ribosomal Subunit Ribosome Nuclear Body Ribonucleoprotein Complex
	Molecular Function	Protease Binding Signaling Receptor Binding Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Norepinephrine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity Dopamine Binding Amine Binding Protein-containing Complex Binding Metal Ion Binding Protein Phosphatase 2A Binding Heterocyclic Compound Binding	Structural Constituent Of Ribosome Protein Binding
	Biological Process	Neurotransmitter Uptake Neurotransmitter Transport Amino Acid Transport Lactation Sensory Perception Of Smell Locomotory Behavior Response To Xenobiotic Stimulus Response To Iron Ion Monoamine Transport Dopamine Transport Adenohypophysis Development Response To Nicotine Sodium Ion Transmembrane Transport Positive Regulation Of Multicellular Organism Growth Regulation Of Dopamine Metabolic Process Response To Cocaine Dopamine Biosynthetic Process Dopamine Catabolic Process Response To Ethanol Cognition Dopamine Uptake Involved In Synaptic Transmission Response To CAMP Norepinephrine Uptake Prepulse Inhibition Dopamine Uptake Hyaloid Vascular Plexus Regression	Translation Mitochondrial Translation
Pathways		Dopamine clearance from the synaptic cleft SLC-mediated transport of neurotransmitters Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS)	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination Mitochondrial ribosome-associated quality control
Drugs		Amphetamine Phentermine Benzatropine Venlafaxine Loxapine Methylphenidate Meperidine Imipramine Duloxetine Amoxapine Mazindol Procaine Trimipramine Modafinil Phenmetrazine Pseudoephedrine Benzphetamine Cocaine Diethylpropion Dopamine Sertraline Sibutramine Chlorpheniramine Diphenylpyraline Nefazodone Bupropion Chloroprocaine Escitalopram Aripiprazole Ephedra sinica root MMDA Midomafetamine Fencamfamin 4-Methoxyamphetamine Dextroamphetamine Metamfetamine Vanoxerine Nomifensine Altropane Mianserin Tesofensine Trodusquemine Armodafinil Desvenlafaxine Dexmethylphenidate Dasotraline Solriamfetol Serdexmethylphenidate
Diseases
GWAS		Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725) Pancreatic cancer ( 25086665)	Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627)
Interacting Genes		9 interacting genes: DRD2 MTNR1A NEDD4 PICK1 RACK1 SNCA SNTA1 STX1A TGFB1I1	2 interacting genes: CIDEB RRAS
Entrez ID		6531	64979
HPRD ID		00543	14756
Ensembl ID		ENSG00000142319	ENSG00000171421
Uniprot IDs		Q01959	Q9P0J6
PDB IDs		8VBY 8Y2C 8Y2D 8Y2E 8Y2F 8Y2G 9EO4	3J7Y 3J9M 5OOL 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5J 7A5K 7L08 7L20 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF4 7OF5 7OF6 7OF7 7OG4 7OIC 7OID 7OIE 7PD3 7QH7 7QI4 7QI5 7QI6 8ANY 8K2A 8K2B 8OIR 8OIT 8QSJ 8RRI 8XT0 8XT1 8XT2 8XT3
Enriched GO Terms of Interacting Partners?		Regulation Of Membrane Potential Monoamine Transport Regulation Of Catecholamine Secretion Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Transport Regulation Of Sodium Ion Transport Receptor Internalization Regulation Of Vesicle-mediated Transport Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Transport Regulation Of Amine Transport Catecholamine Uptake Dopamine Uptake SNARE Complex Assembly Neurotransmitter Transport Regulation Of Endocytosis Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Regulation Of Metal Ion Transport Presynaptic Membrane Dopamine Transport Neurotransmitter Reuptake Synaptic Vesicle Membrane Regulation Of Neurotransmitter Uptake Positive Regulation Of Neurotransmitter Secretion Synaptic Vesicle Transmembrane Transporter Binding Positive Regulation Of Synaptic Transmission Regulation Of Dopamine Secretion Regulation Of Monoatomic Ion Transport Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Regulation Of Protein Transport Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Endocytosis Endocytosis Regulation Of Insulin Secretion Regulation Of Protein Localization Positive Regulation Of Receptor Internalization Neurotransmitter Uptake Receptor-mediated Endocytosis Dopamine Metabolic Process Ionotropic Glutamate Receptor Binding Response To Iron Ion Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Exocytosis Ribosome Regulation Of Peptide Hormone Secretion Regulation Of Synaptic Plasticity Regulation Of Establishment Of Protein Localization	Positive Regulation Of Endothelial Cell-matrix Adhesion Via Fibronectin Protein-containing Complex Binding Schwann Cell Migration Negative Regulation Of Glial Cell Migration Negative Regulation Of Schwann Cell Migration Hyaloid Vascular Plexus Regression Norepinephrine Uptake Dopamine Uptake Involved In Synaptic Transmission Catecholamine Catabolic Process Amine Binding Heterocyclic Compound Binding Monoamine Transmembrane Transporter Activity Norepinephrine:sodium Symporter Activity Dopamine Binding Norepinephrine Transport Dopamine Biosynthetic Process Dopamine:sodium Symporter Activity Adenohypophysis Development Dopamine Catabolic Process Flotillin Complex Lipid Droplet Fusion Catecholamine Uptake Dopamine Uptake Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Vasculogenesis Dopaminergic Synapse Prepulse Inhibition Anatomical Structure Regression COPI-coated Vesicle Lipid Transfer Activity Regulation Of Vasculogenesis Neurotransmitter Transmembrane Transporter Activity COPII Vesicle Coat Regulation Of Dopamine Metabolic Process Dopamine Transport Neurotransmitter Reuptake Catecholamine Biosynthetic Process COPII-coated Vesicle Cargo Loading Regulation Of Glial Cell Migration Plasma Lipoprotein Particle Assembly Execution Phase Of Apoptosis Phosphatidic Acid Binding Protein-lipid Complex Assembly Glial Cell Migration Protein Phosphatase 2A Binding Monoamine Transport Neurotransmitter Uptake Face Morphogenesis Response To Iron Ion Positive Regulation Of Multicellular Organism Growth
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