PRIM1 and SLC26A8

		PRIM1	SLC26A8
Description		DNA primase subunit 1	solute carrier family 26 member 8
Image			No pdb structure
GO Annotations	Cellular Component	DNA-directed RNA Polymerase Complex Nucleoplasm Alpha DNA Polymerase:primase Complex Membrane	Plasma Membrane Membrane Sperm Annulus
	Molecular Function	Magnesium Ion Binding DNA-directed RNA Polymerase Activity Protein Binding Zinc Ion Binding Transferase Activity Nucleotidyltransferase Activity Ribonucleotide Binding Metal Ion Binding	Chloride Channel Activity Protein Binding Sulfate Transmembrane Transporter Activity Antiporter Activity Oxalate Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity Sulfate:chloride Antiporter Activity
	Biological Process	DNA Replication DNA Replication, Synthesis Of Primer DNA Replication Initiation	Monoatomic Ion Transport Chloride Transport Spermatogenesis Oxalate Transport Cell Differentiation Meiotic Cell Cycle Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways		Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand Defective pyroptosis
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31619474) Height ( 31562340) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menopause (age at onset) ( 22267201 26414677) Monocyte count ( 32888494) Plateletcrit ( 27863252 32888494) Red blood cell count ( 29403010)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Appendicular lean mass ( 33097823) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		5 interacting genes: MDC1 MRPL38 OGT PRIM2 TP53	1 interacting genes: RACGAP1
Entrez ID		5557	116369
HPRD ID		08899	12241
Ensembl ID		ENSG00000198056	ENSG00000112053
Uniprot IDs		P49642	Q96RN1
PDB IDs		4BPU 4BPW 4BPX 4LIK 4LIL 4MHQ 4RR2 5EXR 6R4S 6R4T 6R4U 6R5D 6R5E 6RB4 7OPL 7U5C 8B9D 8D0B 8D0K 8D9D 8QJ7 8VY3 9C8V
Enriched GO Terms of Interacting Partners?		Nucleoplasm DNA-binding Transcription Factor Activity Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Transcription Regulator Complex Nickel Cation Transmembrane Transporter Activity Nickel Cation Transport Nickel Cation Transmembrane Transport Solute:proton Symporter Activity Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Cobalt Ion Transmembrane Transporter Activity Transition Metal Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Cadmium Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity Calmodulin-activated Dual Specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-activated 3',5'-cyclic-GMP Phosphodiesterase Activity Macromolecule Biosynthetic Process Growth Plate Cartilage Chondrocyte Growth Stem Cell Proliferation Negative Regulation Of Stem Cell Proliferation Regulation Of Stem Cell Proliferation Positive Regulation Of DNA Recombination Isotype Switching To IgE Isotypes Transcription Coactivator Binding Mammary Gland Morphogenesis T Cell Lineage Commitment Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Negative Regulation Of Pentose-phosphate Shunt Regulation Of Programmed Necrotic Cell Death Negative Regulation Of Helicase Activity Regulation Of Carbohydrate Catabolic Process Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Autophagy Of Mitochondrion Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Mitotic DNA Integrity Checkpoint Signaling Negative Regulation Of Proteolysis Germ Cell Nucleus Cellular Response To Actinomycin D Mitophagy	Ribonucleotide Binding Centralspindlin Complex Actomyosin Contractile Ring Assembly Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer Mitotic Spindle Midzone Assembly Sulfate Transmembrane Transport Spindle Midzone Assembly DNA Replication Initiation DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex Cortical Actin Cytoskeleton Organization Flemming Body Regulation Of Attachment Of Spindle Microtubules To Kinetochore Alpha-tubulin Binding Neuroblast Proliferation Cortical Cytoskeleton Organization Phosphatidylinositol-3,4,5-trisphosphate Binding Gamma-tubulin Binding Positive Regulation Of Cytokinesis Beta-tubulin Binding Cytokinetic Process Spindle Midzone Cleavage Furrow Mitotic Cytokinesis Rho Protein Signal Transduction Erythrocyte Differentiation Nucleotidyltransferase Activity Positive Regulation Of Cell Division Cytoskeleton-dependent Cytokinesis Regulation Of Cytokinesis Neural Precursor Cell Proliferation Regulation Of Embryonic Development Zinc Ion Binding Cytoplasmic Side Of Plasma Membrane Actomyosin Structure Organization Acrosomal Vesicle Inorganic Anion Transmembrane Transport Inorganic Anion Transport Mitotic Spindle
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